Lbx1 - ladybird homeobox 1 Gene

Also Known as Lbx1h

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16814

Summary

Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including heart looping; negative regulation of neuron differentiation; and neuron differentiation. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; skeletal musculature; and urinary system. Orthologous to human LBX1 (ladybird homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Lbx1 Products (1)

mRNA	Protein	Name
NM_010691.6	NP_034821.2	transcription factor LBX1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15528197	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15528197	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12522123	MGI
acts upstream of glutamatergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	16234809	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	12522123	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12522123	MGI
acts upstream of or within negative regulation of glutamatergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	16234809	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	12062039	MGI
acts upstream of or within neuron fate determination	IGI IGI: Inferred from genetic interaction	16234809	MGI
acts upstream of or within neuron fate determination	IMP IMP: Inferred from mutant phenotype	16234809	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15528197	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12062038	MGI
acts upstream of or within spinal cord motor neuron differentiation	IGI IGI: Inferred from genetic interaction	15769945	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15528197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor LBX1	lady bird-like homeobox 1 homolog ladybird homeobox protein homolog 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07546	LBX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lbx1	NCBI	NCBI:10660