Lhx3 - LIM homeobox protein 3 Gene

Mus musculus

Also known as Lim3; P-LIM; mLIM3; mLim-3

Gene ID: 16871 | Gene type: protein coding

About Lhx3

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including nervous system development; placenta development; and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX3 (LIM homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Lhx3 Products(2)

mRNA	Protein	Name
NM_001039653.2	NP_001034742.1	LIM/homeobox protein Lhx3 isoform a
NM_010711.2	NP_034841.2	LIM/homeobox protein Lhx3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10431247	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18539116	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	18539116	MGI
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	18539116	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	18037398	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	18037398	MGI
acts upstream of or within medial motor column neuron differentiation	IGI IGI: Inferred from genetic interaction	9865699	MGI
acts upstream of or within motor neuron axon guidance	IGI IGI: Inferred from genetic interaction	9865699	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18037398	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	18037398	MGI
acts upstream of or within placenta development	IGI IGI: Inferred from genetic interaction	18425848	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10593900	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9192866	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9192866	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18539116	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18539116	MGI
acts upstream of or within prolactin secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	8638120	MGI
acts upstream of or within somatotropin secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	8638120	MGI
acts upstream of or within spinal cord association neuron differentiation	IDA IDA: Inferred from direct assay	19323994	MGI
acts upstream of or within spinal cord motor neuron cell fate specification	IGI IGI: Inferred from genetic interaction	19666821	MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	8638120	MGI
acts upstream of or within ventral spinal cord interneuron specification	IDA IDA: Inferred from direct assay	19666821	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	18539116	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10482234	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9192866	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

LIM/homeobox protein Lhx3

LIM homeo box protein 3	homeobox protein LIM-3
homeobox protein P-LIM

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07633	LHX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174591	Human LHX3 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lhx3	NCBI	NCBI:8022

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