Gzmm - granzyme M (lymphocyte met-ase 1) Gene

Also Known as Lmet1; MMET-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16904

Summary

The protein encoded by this gene is a member of a family of cytotoxic lymphocyte serine proteases called granzymes, which are expressed by cytotoxic T lymphocytes and natural killer cells. This protein belongs to a subfamily of granzymes that cleave after methionine residues. Natural killer cell development, homeostasis and cytotoxicity are normal in mice deficient for this gene, but they demonstrate increased susceptibility to murine cytomegalovirus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Gzmm Products (3)

mRNA Protein Name
NM_001302485.1 NP_001289414.1 granzyme M isoform 2 precursor
NM_001302499.1 NP_001289428.1 granzyme M isoform 3
NM_008504.3 NP_032530.1 granzyme M isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
15454490 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15454490 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15454490 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

granzyme M

  • lymphoctye Met-ase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05943 GZMM Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gzmm NCBI NCBI:3004