Ltbp3 - latent transforming growth factor beta binding protein 3 Gene

Also Known as Ltbp2; mFLJ00070

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16998

Summary

Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within several processes, including negative regulation of bone mineralization; negative regulation of chondrocyte differentiation; and positive regulation of bone resorption. Located in extracellular region. Is expressed in several structures, including cardiovascular system; jaw; limb; respiratory system; and ventricular layer. Used to study brachyolmia-amelogenesis imperfecta syndrome. Human ortholog(s) of this gene implicated in brachyolmia-amelogenesis imperfecta syndrome and geleophysic dysplasia 3. Orthologous to human LTBP3 (latent transforming growth factor beta binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Ltbp3 Products (1)

mRNA Protein Name
NM_008520.3 NP_032546.2 latent-transforming growth factor beta-binding protein 3 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of bone mineralization IMP
IMP: Inferred from mutant phenotype
11790802 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
11790802 MGI
acts upstream of or within bone remodeling IMP
IMP: Inferred from mutant phenotype
11790802 MGI
acts upstream of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11790802 MGI
acts upstream of or within lung saccule development IMP
IMP: Inferred from mutant phenotype
16049328 MGI
acts upstream of or within negative regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
11790802 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11790802 MGI
acts upstream of or within positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
15878314 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
12379497 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12379497 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IPI
IPI: Inferred from physical interaction
7730318 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
7730318 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

latent-transforming growth factor beta-binding protein 3

  • LTBP-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07878 LTBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07879 LTBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ltbp3 NCBI NCBI:4054