Nphs2 - nephrosis 2, podocin Gene

Also Known as PDCN; SRN1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170484

Summary

Predicted to be involved in actin Cytoskeleton reorganization. Located in plasma membrane. Is intrinsic component of the cytoplasmic side of the plasma membrane. Colocalizes with slit diaphragm. Is expressed in liver; metanephros; and ureter. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 2. Orthologous to human NPHS2 (NPHS2 stomatin family member, podocin). [provided by Alliance of Genome Resources, Apr 2022]

Nphs2 Products (1)

mRNA Protein Name
NM_130456.4 NP_569723.1 podocin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11733557 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16501493 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell periphery IDA
IDA: Inferred from direct assay
16501493 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
11786407 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11733557 MGI
colocalizes with slit diaphragm IDA
IDA: Inferred from direct assay
11786407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

podocin

  • nephrosis 2 homolog, podocin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09487 NPHS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nphs2 NCBI NCBI:7827