Cntnap4 - contactin associated protein-like 4 Gene

Also Known as Caspr4; E130114F09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 170571

Summary

Involved in modulation of chemical synaptic transmission; regulation of grooming behavior; and regulation of synapse organization. Located in dendrite and presynaptic membrane. Is integral component of presynaptic membrane. Is active in GABA-ergic synapse. Is expressed in brain. Orthologous to human CNTNAP4 (contactin associated protein family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Cntnap4 Products (1)

mRNA	Protein	Name
NM_130457.2	NP_569724.2	contactin-associated protein-like 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	25279559	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12093160	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	24870235	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	24870235	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	25279559	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	25279559	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	25279559	MGI
involved in regulation of grooming behavior	IMP IMP: Inferred from mutant phenotype	24870235	MGI
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	24870235	MGI
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	24870235	MGI
involved in regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	24870235	MGI
involved in regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	24870235	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	24870235	MGI
is active in GABA-ergic synapse	IEP IEP: Inferred from expression pattern	24870235	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	24870235	MGI
located in dendrite	IDA IDA: Inferred from direct assay	12093160	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	25279559	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24870235	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	24870235	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	24870235	MGI
is active in presynaptic membrane	IMP IMP: Inferred from mutant phenotype	24870235	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
contactin-associated protein-like 4	cell recognition molecule Caspr4 cell recognition protein CASPR4 contactin associated protein 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02936	CNTNAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cntnap4	NCBI	NCBI:85445