ADAMTS16 - ADAM metallopeptidase with thrombospondin type 1 motif 16 Gene

Also Known as ADAMTS16s

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 170690

About ADAMTS16

Cytogenetic location: 5p15.32 Genomic coordinates (GRCh38): 5:5,140,330-5,320,304 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 25 paralogues. Biased expression in ovary (RPKM 5.4), gall bladder (RPKM 4.3) and 8 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]

ADAMTS16 Products (1)

mRNA Protein Name
NM_139056.4 NP_620687.2 A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein

ADAMTS16 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (60 - 205)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (292 - 495)

TSP_1

TSP_1: Thrombospondin type 1 domain (590 - 640)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (748 - 858)

TSP_1

TSP_1: Thrombospondin type 1 domain (934 - 986)

TSP_1

TSP_1: Thrombospondin type 1 domain (993 - 1031)

TSP_1

TSP_1: Thrombospondin type 1 domain (1058 - 1081)

TSP_1

TSP_1: Thrombospondin type 1 domain (1133 - 1169)

PLAC

PLAC: PLAC (protease and lacunin) domain (1190 - 1221)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1224 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 16

  • ADAM-TS 16

Related Diseases

Diseases Alias
Weill-Marchesani Syndrome

  • Gemss Syndrome

  • Spherophakia-Brachymorphia Syndrome

  • Marchesani-Weill Syndrome

  • Wms

  • Congenital Mesodermal Dystrophy

  • Mesodermal Dysmorphodystrophy, Congenital

  • Spherophakia Brachymorphia Syndrome

  • Mesodermal Dysmorphodystrophy Congenital

  • Wm Syndrome

  • Brachydactyly-Spherophakia Syndrome

  • Brachymorphy With Spherophakia Syndrome

  • Congenital Mesodermal Dysmorphodystrophy

  • Marchesani Syndrome

  • Weill-Marchesani Syndrome, Autosomal Recessive

  • Weill-Marchesani Syndrome, Autosomal Dominant
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00297 ADAMTS16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19099 Adamts16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25588 Adamts16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ADAMTS16 VGNC VGNC:59590
Canis familiaris ADAMTS16 VGNC VGNC:37594
Bos taurus ADAMTS16 VGNC VGNC:25620
Macaca mulatta ADAMTS16 VGNC VGNC:69439
Rattus norvegicus ADAMTS16 RGD RGD:1310046
Mus musculus ADAMTS16 MGD MGI:2429637
Others ADAMTS16 NCBI