Crb1 - crumbs family member 1, photoreceptor morphogenesis associated Gene

Mus musculus

Also known as CRB1-A; CRB1-B; CRB1-C; CRB1-A2; 7530426H14Rik; A930008G09Rik

Gene ID: 170788 | Gene type: protein coding

About Crb1

Summary

Predicted to enable calcium ion binding activity. Involved in visual perception. Acts upstream of with a negative effect on cellular protein localization. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; eye morphogenesis; and neurogenesis. Located in several cellular components, including adherens junction; microvillus; and photoreceptor outer segment. Part of subapical complex. Is active in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; epidermis; genitourinary system; and sensory organ. Used to study Leber congenital amaurosis 8 and retinitis pigmentosa 12. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Apr 2022]

Crb1 Products(1)

mRNA	Protein	Name
NM_133239.2	NP_573502.2	protein crumbs homolog 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15316081	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	25147295	MGI
acts upstream of or within cellular response to light stimulus	IMP IMP: Inferred from mutant phenotype	17234588	MGI
acts upstream of or within detection of light stimulus involved in visual perception	IMP IMP: Inferred from mutant phenotype	22447858	MGI
acts upstream of or within establishment of bipolar cell polarity involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	15316081	MGI
acts upstream of or within eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	12915475	MGI
acts upstream of positive effect gene expression	IMP IMP: Inferred from mutant phenotype	17234588	MGI
acts upstream of or within glial cell differentiation	IMP IMP: Inferred from mutant phenotype	25147295	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	12915475	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	17234588	MGI
acts upstream of or within photoreceptor cell outer segment organization	IMP IMP: Inferred from mutant phenotype	12915475	MGI
acts upstream of or within plasma membrane organization	IMP IMP: Inferred from mutant phenotype	15316081	MGI
acts upstream of or within post-embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	15316081	MGI
involved in post-embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	12915475	MGI
acts upstream of negative effect protein localization	IMP IMP: Inferred from mutant phenotype	16885194	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	22447858	MGI
acts upstream of or within retina layer formation	IMP IMP: Inferred from mutant phenotype	17234588	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	17234588	MGI
involved in retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	12915475	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	15316081	MGI
involved in visual perception	IMP IMP: Inferred from mutant phenotype	12915475	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	15316081	MGI
located in apical junction complex	IDA IDA: Inferred from direct assay	15316081	MGI
is active in apical part of cell	IDA IDA: Inferred from direct assay	25636444	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	17234588	MGI
located in glial cell projection	IDA IDA: Inferred from direct assay	129154	MGI
located in microvillus	IDA IDA: Inferred from direct assay	16885194	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	15316081	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16885194	MGI
part of subapical complex	IDA IDA: Inferred from direct assay	16885194	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein crumbs homolog 1

crumbs homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03140	CRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crb1	NCBI	NCBI:23418

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