Crb1 - crumbs family member 1, photoreceptor morphogenesis associated Gene

Also Known as CRB1-A; CRB1-B; CRB1-C; CRB1-A2; 7530426H14Rik; A930008G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170788

Summary

Predicted to enable calcium ion binding activity. Involved in visual perception. Acts upstream of with a negative effect on cellular protein localization. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; eye morphogenesis; and neurogenesis. Located in several cellular components, including adherens junction; microvillus; and photoreceptor outer segment. Part of subapical complex. Is active in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; epidermis; genitourinary system; and sensory organ. Used to study Leber congenital amaurosis 8 and retinitis pigmentosa 12. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Apr 2022]

Crb1 Products (1)

mRNA Protein Name
NM_133239.2 NP_573502.2 protein crumbs homolog 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15316081 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
25147295 MGI
acts upstream of or within cellular response to light stimulus IMP
IMP: Inferred from mutant phenotype
17234588 MGI
acts upstream of or within detection of light stimulus involved in visual perception IMP
IMP: Inferred from mutant phenotype
22447858 MGI
acts upstream of or within establishment of bipolar cell polarity involved in cell morphogenesis IMP
IMP: Inferred from mutant phenotype
15316081 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
12915475 MGI
acts upstream of positive effect gene expression IMP
IMP: Inferred from mutant phenotype
17234588 MGI
acts upstream of or within glial cell differentiation IMP
IMP: Inferred from mutant phenotype
25147295 MGI
acts upstream of or within membrane organization IMP
IMP: Inferred from mutant phenotype
12915475 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
17234588 MGI
acts upstream of or within photoreceptor cell outer segment organization IMP
IMP: Inferred from mutant phenotype
12915475 MGI
acts upstream of or within plasma membrane organization IMP
IMP: Inferred from mutant phenotype
15316081 MGI
acts upstream of or within post-embryonic retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
15316081 MGI
involved in post-embryonic retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
12915475 MGI
acts upstream of negative effect protein localization IMP
IMP: Inferred from mutant phenotype
16885194 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
22447858 MGI
acts upstream of or within retina layer formation IMP
IMP: Inferred from mutant phenotype
17234588 MGI
acts upstream of or within retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
17234588 MGI
involved in retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
12915475 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
15316081 MGI
involved in visual perception IMP
IMP: Inferred from mutant phenotype
12915475 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
15316081 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
15316081 MGI
is active in apical part of cell IDA
IDA: Inferred from direct assay
25636444 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
17234588 MGI
located in glial cell projection IDA
IDA: Inferred from direct assay
129154 MGI
located in microvillus IDA
IDA: Inferred from direct assay
16885194 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
15316081 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16885194 MGI
part of subapical complex IDA
IDA: Inferred from direct assay
16885194 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein crumbs homolog 1

  • crumbs homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03140 CRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crb1 NCBI NCBI:23418