Mlc1 - megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) Gene

Also Known as VL; LVM; MLC; WKL1; Kiaa0027-hp

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170790

Summary

Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including caveolin-mediated endocytosis; cellular response to cholesterol; and regulation of response to osmotic stress. Predicted to act upstream of or within ion transport. Located in several cellular components, including apical plasma membrane; astrocyte end-foot; and cell-cell junction. Is expressed in several structures, including central nervous system; eye; gut; and male reproductive gland or organ. Used to study megalencephalic leukoencephalopathy with subcortical cysts 1. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 1. Orthologous to human MLC1 (modulator of VRAC current 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlc1 Products (2)

mRNA Protein Name
NM_001364855.1 NP_001351784.1 membrane protein MLC1 isoform 2
NM_133241.2 NP_573504.1 membrane protein MLC1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
15367490 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21419380 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
15367490 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15367490 MGI
located in astrocyte end-foot IDA
IDA: Inferred from direct assay
15367490 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
15367490 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15367490 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15367490 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

membrane protein MLC1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08485 MLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08909 MYL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlc1 NCBI NCBI:23209