Mlc1 - megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) Gene

Mus musculus

Also known as VL; LVM; MLC; WKL1; Kiaa0027-hp

Gene ID: 170790 | Gene type: protein coding

About Mlc1

Summary

Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including caveolin-mediated endocytosis; cellular response to cholesterol; and regulation of response to osmotic stress. Predicted to act upstream of or within ion transport. Located in several cellular components, including apical plasma membrane; astrocyte end-foot; and cell-cell junction. Is expressed in several structures, including central nervous system; eye; gut; and male reproductive gland or organ. Used to study megalencephalic leukoencephalopathy with subcortical cysts 1. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 1. Orthologous to human MLC1 (modulator of VRAC current 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlc1 Products(2)

mRNA	Protein	Name
NM_001364855.1	NP_001351784.1	membrane protein MLC1 isoform 2
NM_133241.2	NP_573504.1	membrane protein MLC1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	15367490	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21419380	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	15367490	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15367490	MGI
located in astrocyte end-foot	IDA IDA: Inferred from direct assay	15367490	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	15367490	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15367490	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15367490	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

membrane protein MLC1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08485	MLC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08909	MYL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mlc1	NCBI	NCBI:23209

Name
Email *

	Sorry, but the email address you supplied was invalid.