Ppargc1b - peroxisome proliferative activated receptor, gamma, coactivator 1 beta Gene

Also Known as Perc; PGC-1beta; 4631412G21Rik; PPARGC-1-beta; PGC-1beta/ERRL1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 170826

Summary

Predicted to enable AF-2 domain binding activity; Estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in several processes, including bone trabecula formation; positive regulation of phosphate metabolic process; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in brown fat; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ppargc1b Products (2)

mRNA	Protein	Name
NM_001364996.1	NP_001351925.1	peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
NM_133249.3	NP_573512.1	peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17276355	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in bone trabecula formation	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	19252502	MGI
involved in mitochondrial transcription	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in ossification	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in positive regulation of alkaline phosphatase activity	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	17090215	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in positive regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	19252502	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
peroxisome proliferator-activated receptor gamma coactivator 1-beta	ERR ligand 1 PPAR gamma coactivator-1beta protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10931	PPARGC1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppargc1b	NCBI	NCBI:133522