KCNG3 - potassium voltage-gated channel modifier subfamily G member 3 Gene

Also Known as KV6.3; KV10.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 170850

About KCNG3

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,388,352-42,493,982 (from NCBI)

This gene has 2 transcripts (splice variants), 182 orthologues and 31 paralogues. Low expression observed in reference dataset.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KCNG3 Products (2)

mRNA	Protein	Name
NM_133329.6	NP_579875.1	potassium voltage-gated channel subfamily G member 3 isoform 1
NM_172344.3	NP_758847.1	potassium voltage-gated channel subfamily G member 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	11852086	GOA
enables potassium channel regulator activity	IGI IGI: Inferred from genetic interaction	15046870	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11852086	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	19074135	GOA
involved in regulation of potassium ion transport	IDA IDA: Inferred from direct assay	11852086	GOA
acts upstream of or within regulation of potassium ion transport	IGI IGI: Inferred from genetic interaction	15046870	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12060745	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12060745	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	19074135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNG3 Protein Structure

BTB_2

Ion_trans

0
100
200
300
400
436 a.a.

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily G member 3	potassium channel, voltage gated modifier subfamily G, member 3

Related Diseases

Diseases	Alias
Retinal Cone Dystrophy 3b	RCD3B Cone Dystrophy With Supernormal Rod Response Cone Dystrophy With Supernormal Rod Electroretinogram Cone Dystrophy With Supernormal Rod Responses Cdsrr Cone Dystrophy With Night Blindness And Supernormal Rod Responses, Kcnv2-Related Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2 Related Cone Dystrophy With Supernormal Rod Erg Cone Dystrophy With Supernormal Scotopic Electroretinogram Cone Dystrophy Retinal 3b Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2-Related Doid:0081022 Dystrophy, Retinal Cone, Type 3b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07123	KCNG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNG3	VGNC	VGNC:42246
Rattus norvegicus	KCNG3	RGD	RGD:628832
Bos taurus	KCNG3	VGNC	VGNC:58383
Macaca mulatta	KCNG3	VGNC	VGNC:106175
Mus musculus	KCNG3	MGD	MGI:2663923
Others	KCNG3	NCBI