Lonp1 - lon peptidase 1, mitochondrial Gene

Also Known as Lon; Prss15

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170916

Summary

Enables ATP-dependent peptidase activity. Involved in several processes, including aging; response to aluminum ion; and response to hypoxia. Located in mitochondrial matrix. Used to study brain ischemia and ischemia. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

Lonp1 Products (1)

mRNA Protein Name
NM_133404.1 NP_596895.1 lon protease homolog, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent peptidase activity IDA
IDA: Inferred from direct assay
12752449 RGD
Biological Process GO Annotation Evidence References Source
involved in mitochondrion organization IEP
IEP: Inferred from expression pattern
10050756 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
12752449 RGD
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
12082077 RGD
involved in response to aluminum ion IEP
IEP: Inferred from expression pattern
19010380 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
10050756 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12082077 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
15560797 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lon protease homolog, mitochondrial

  • LONP

  • lon protease-like protein

  • mitochondrial ATP-dependent protease Lon

  • protease, serine, 15

  • serine protease 15

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153034 LONP1-IN-2 99.43% Unkown
HY-158412 BT317 99.81% Unkown
HY-RS07734 LONP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24767 Lonp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18289 Lonp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lonp1 NCBI NCBI:9361