Chrna2 - cholinergic receptor nicotinic alpha 2 subunit Gene

Also Known as ACHR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170945

Summary

Enables acetylcholine-gated cation-selective channel activity and quaternary ammonium group binding activity. Contributes to heterocyclic compound binding activity. Involved in response to acetylcholine. Located in membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna2 Products (1)

mRNA Protein Name
NM_133420.1 NP_596911.1 neuronal acetylcholine receptor subunit alpha-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: Inferred from direct assay
2832952 RGD
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
15016836 RGD
contributes to heterocyclic compound binding IPI
IPI: Inferred from physical interaction
16129735 RGD
enables quaternary ammonium group binding IDA
IDA: Inferred from direct assay
15016836 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to nicotine IDA
IDA: Inferred from direct assay
19385992 RGD
involved in modulation of inhibitory postsynaptic potential IDA
IDA: Inferred from direct assay
19385992 RGD
involved in response to acetylcholine IDA
IDA: Inferred from direct assay
15016836 RGD
Cellular Component GO Annotation Evidence References Source
located in neuron projection cytoplasm IDA
IDA: Inferred from direct assay
19385992 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16129735 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-2

  • cholinergic receptor, nicotinic, alpha 2 (neuronal)

  • cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)

  • nicotinic acetylcholine receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02667 CHRNA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna2 NCBI NCBI:1135