Kcne2 - potassium voltage-gated channel subfamily E regulatory subunit 2 Gene

Also Known as Mirp1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171138

Summary

Enables several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Contributes to delayed rectifier Potassium Channel activity and inward rectifier Potassium Channel activity. Involved in several processes, including ion transmembrane transport; regulation of ion transmembrane transport; and tongue development. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Is integral component of membrane. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcne2 Products (1)

mRNA Protein Name
NM_133603.2 NP_598287.1 potassium voltage-gated channel subfamily E member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
10219239 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19913309 RGD
contributes to inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
10219239 RGD
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
10219239 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14679187 RGD
enables transmembrane transporter binding IDA
IDA: Inferred from direct assay
10219239 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
19219384 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
15292247 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
10219239 RGD
involved in membrane repolarization IDA
IDA: Inferred from direct assay
10219239 RGD
involved in membrane repolarization during action potential IDA
IDA: Inferred from direct assay
10219239 RGD
involved in negative regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
19219384 RGD
involved in negative regulation of voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
14679187 RGD
involved in positive regulation of voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
14679187 RGD
involved in potassium ion export across plasma membrane IDA
IDA: Inferred from direct assay
10219239 RGD
involved in potassium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
10219239 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
10219239 RGD
involved in regulation of cyclic nucleotide-gated ion channel activity IDA
IDA: Inferred from direct assay
11420311 RGD
involved in regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
10219239 RGD
involved in regulation of membrane repolarization IDA
IDA: Inferred from direct assay
10219239 RGD
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
10219239 RGD
involved in tongue development IEP
IEP: Inferred from expression pattern
15365256 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21943416 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19219384 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
10219239 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily E member 2

  • minK-related peptide 1

  • minimum potassium ion channel-related peptide 1

  • potassium channel subunit beta MiRP1

  • potassium channel, voltage gated subfamily E regulatory beta subunit 2

  • potassium channel, voltage-gated Isk-related subfamily E regulatory beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07116 KCNE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121977 IKs124 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcne2 NCBI NCBI:9992