Kcne2 - potassium voltage-gated channel subfamily E regulatory subunit 2 Gene

Rattus norvegicus

Also known as Mirp1

Gene ID: 171138 | Gene type: protein coding

About Kcne2

Summary

Enables several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Contributes to delayed rectifier Potassium Channel activity and inward rectifier Potassium Channel activity. Involved in several processes, including ion transmembrane transport; regulation of ion transmembrane transport; and tongue development. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Is integral component of membrane. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcne2 Products(1)

mRNA	Protein	Name
NM_133603.2	NP_598287.1	potassium voltage-gated channel subfamily E member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	10219239	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19913309	RGD
contributes to inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	10219239	RGD
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	10219239	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14679187	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	10219239	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19219384	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	15292247	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	10219239	RGD
involved in membrane repolarization	IDA IDA: Inferred from direct assay	10219239	RGD
involved in membrane repolarization during action potential	IDA IDA: Inferred from direct assay	10219239	RGD
involved in negative regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	19219384	RGD
involved in negative regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	14679187	RGD
involved in positive regulation of voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	14679187	RGD
involved in potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10219239	RGD
involved in potassium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	10219239	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	10219239	RGD
involved in regulation of cyclic nucleotide-gated ion channel activity	IDA IDA: Inferred from direct assay	11420311	RGD
involved in regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	10219239	RGD
involved in regulation of membrane repolarization	IDA IDA: Inferred from direct assay	10219239	RGD
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	10219239	RGD
involved in tongue development	IEP IEP: Inferred from expression pattern	15365256	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21943416	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	19219384	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	10219239	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily E member 2

minK-related peptide 1	minimum potassium ion channel-related peptide 1
potassium channel subunit beta MiRP1	potassium channel, voltage gated subfamily E regulatory beta subunit 2
potassium channel, voltage-gated Isk-related subfamily E regulatory beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07116	KCNE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121977	IKs124	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcne2	NCBI	NCBI:9992

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