2. Gene
  3. Eif2b3 - eukaryotic translation initiation factor 2B subunit gamma Gene

Eif2b3 - eukaryotic translation initiation factor 2B subunit gamma Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 171145 | Gene type: protein coding

About Eif2b3

Summary

Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; response to glucose; and response to heat. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b3 Products(1)

mRNA Protein Name
NM_133609.2 NP_598293.2 translation initiation factor eIF-2B subunit gamma
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9582312 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9139680 RGD
Biological Process GO Annotation Evidence Reference Source
involved in hippocampus development IEP
IEP: Inferred from expression pattern
12850562 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
8567668 RGD
involved in response to heat IDA
IDA: Inferred from direct assay
9341116 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
8430778 RGD
Cellular Component GO Annotation Evidence Reference Source
part of eukaryotic translation initiation factor 2B complex IDA
IDA: Inferred from direct assay
9139680 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

translation initiation factor eIF-2B subunit gamma

eIF-2B GDP-GTP exchange factor subunit gamma

eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD)

eukaryotic translation initiation factor 2B, subunit 3 gamma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04250 EIF2B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2b3 NCBI NCBI:8891