Ntng2 - netrin G2 Gene

Also Known as Lmnt2; 2610016D08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 171171

Summary

The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Ntng2 Products (3)

mRNA	Protein	Name
NM_001305805.1	NP_001292734.1	netrin-G2 isoform c precursor
NM_133500.2	NP_598007.1	netrin-G2 isoform a precursor
NM_133501.2	NP_598008.1	netrin-G2 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16980967	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	11804778	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	25411505	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	25411505	MGI
involved in postsynaptic specialization assembly	IDA IDA: Inferred from direct assay	16980967	MGI
involved in postsynaptic specialization assembly	IMP IMP: Inferred from mutant phenotype	16980967	MGI
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	31692205	MGI
involved in regulation of neuron projection arborization	IMP IMP: Inferred from mutant phenotype	31692205	MGI
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	31692205	MGI
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	16980967	MGI
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	16980967	MGI
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	16980967	MGI
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	16980967	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	25411505	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	25411505	MGI
located in axon	IDA IDA: Inferred from direct assay	16980967	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16980967	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16980967	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11804778	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	25411505	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
netrin-G2	laminet 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09626	NTNG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntng2	NCBI	NCBI:84628