2. Gene
  3. Mad1l1 - MAD1 mitotic arrest deficient 1-like 1 Gene

Mad1l1 - MAD1 mitotic arrest deficient 1-like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mad1

Gene ID: 17120 | Gene type: protein coding

About Mad1l1

Summary

Predicted to enable identical protein binding activity and kinetochore binding activity. Acts upstream of or within negative regulation of T cell proliferation; regulation of mitotic cell cycle phase transition; and thymus development. Located in cytoplasm; kinetochore; and spindle pole. Human ortholog(s) of this gene implicated in lymphoma and prostate Cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Mad1l1 Products(3)

mRNA Protein Name
NM_001359025.1 NP_001345954.1 mitotic spindle assembly checkpoint protein MAD1 isoform a
NM_001359027.1 NP_001345956.1 mitotic spindle assembly checkpoint protein MAD1 isoform b
NM_010752.3 NP_034882.2 mitotic spindle assembly checkpoint protein MAD1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
36357673 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
11313860 MGI
acts upstream of or within regulation of mitotic cell cycle phase transition IDA
IDA: Inferred from direct assay
11313860 MGI
acts upstream of or within thymus development IDA
IDA: Inferred from direct assay
11313860 MGI
Cellular Component GO Annotation Evidence Reference Source
part of MAD1 complex IDA
IDA: Inferred from direct assay
22493223 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17504913 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
17504913 MGI
part of mitotic spindle assembly checkpoint MAD1-MAD2 complex IPI
IPI: Inferred from physical interaction
12006501 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
17504913 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitotic spindle assembly checkpoint protein MAD1

MAD1-like protein 1

mitotic arrest deficient 1-like 1

mitotic arrest deficient 1-like protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07948 MAD1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mad1l1 NCBI NCBI:8379