H1f8 - H1.8 linker histone Gene

Also Known as H1-8; H1.8; H1fo; H1oo; H1foo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 171506

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]

H1f8 Products (4)

mRNA Protein Name
NM_001346702.1 NP_001333631.1 histone H1.8 isoform 2
NM_138311.3 NP_612184.1 histone H1.8 isoform 1
NM_001346702.1 NP_001333631.1 histone H1.8 isoform 2
NM_138311.3 NP_612184.1 histone H1.8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nucleosomal DNA binding IDA
IDA: Inferred from direct assay
22868987 MGI
enables structural constituent of chromatin IDA
IDA: Inferred from direct assay
22868987 MGI
Biological Process GO Annotation Evidence References Source
involved in epigenetic regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22868987 MGI
Cellular Component GO Annotation Evidence References Source
located in female germ cell nucleus IDA
IDA: Inferred from direct assay
11171391 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
22868987 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22868987 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H1.8

  • H1 histone family, member O, oocyte-specific

  • histone H1oo

  • oocyte-specific histone H1

  • oocyte-specific linker histone H1