Cyp2d4 - cytochrome P450, family 2, subfamily d, polypeptide 4 Gene

Also Known as Cyp2d6; Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171522

Summary

Enables arachidonic acid monooxygenase activity. Involved in several processes, including C21-steroid hormone metabolic process; arachidonic acid metabolic process; and phenol-containing compound biosynthetic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; asthma; autoimmune hepatitis; and rhinitis. Orthologous to several human genes including CYP2D6 (Cytochrome P450 family 2 subfamily D member 6). [provided by Alliance of Genome Resources, Apr 2022]

Cyp2d4 Products (2)

mRNA Protein Name
NM_138515.2 NP_612524.1 cytochrome P450 2D4
NM_138515.2 NP_612524.1 cytochrome P450 2D4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables arachidonate monooxygenase activity IDA
IDA: Inferred from direct assay
10945868 RGD
enables monooxygenase activity IDA
IDA: Inferred from direct assay
8910433 RGD
enables progesterone 21-hydroxylase activity IDA
IDA: Inferred from direct assay
11517168 RGD
Biological Process GO Annotation Evidence References Source
involved in C21-steroid hormone metabolic process IMP
IMP: Inferred from mutant phenotype
14563706 RGD
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
10945868 RGD
involved in dopamine biosynthetic process IDA
IDA: Inferred from direct assay
19818757 RGD
involved in dopamine metabolic process IDA
IDA: Inferred from direct assay
10945868 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18342837 RGD
involved in oxidative demethylation IMP
IMP: Inferred from mutant phenotype
19059219 RGD
involved in response to toluene IEP
IEP: Inferred from expression pattern
14703099 RGD
involved in serotonin biosynthetic process from tryptophan IDA
IDA: Inferred from direct assay
23098818 RGD
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
8910433 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 2D4

  • CYPIID18

  • CYPIID4

  • Cytochrome P450, subfamily IID4

  • P450 2D-29/2D-35

  • P450-CMF3

  • P450-DB4

  • cytochrome P450 2D-29

  • cytochrome P450 2D-35

  • cytochrome P450 2d18

  • cytochrome P450, family 2, subfamily d, polypeptide 22

  • cytochrome P450, subfamily 2D, polypepti

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03461 CYP2D6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03462 CYP2D7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown