Mcf2l - mcf.2 transforming sequence-like Gene

Also Known as Dbs; Ost; mKIAA0362; C130040G20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17207

Summary

Enables 1-phosphatidylinositol binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within Rho protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in lamellipodium and membrane. Is expressed in nervous system and retina. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like). [provided by Alliance of Genome Resources, Apr 2022]

Mcf2l Products (11)

mRNA Protein Name
NM_001159485.2 NP_001152957.1 guanine nucleotide exchange factor DBS isoform 3
NM_001159486.2 NP_001152958.1 guanine nucleotide exchange factor DBS isoform 2
NM_001371043.1 NP_001357972.1 guanine nucleotide exchange factor DBS isoform 4
NM_001371044.1 NP_001357973.1 guanine nucleotide exchange factor DBS isoform 5
NM_001371045.1 NP_001357974.1 guanine nucleotide exchange factor DBS isoform 6 precursor
NM_001371046.1 NP_001357975.1 guanine nucleotide exchange factor DBS isoform 7
NM_001371047.1 NP_001357976.1 guanine nucleotide exchange factor DBS isoform 8
NM_001371048.1 NP_001357977.1 guanine nucleotide exchange factor DBS isoform 9 precursor
NM_001371049.1 NP_001357978.1 guanine nucleotide exchange factor DBS isoform 10
NM_001371050.1 NP_001357979.1 guanine nucleotide exchange factor DBS isoform 11
NM_178076.4 NP_835177.2 guanine nucleotide exchange factor DBS isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol binding IDA
IDA: Inferred from direct assay
12637522 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12637522 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11889037 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rho protein signal transduction IDA
IDA: Inferred from direct assay
12637522 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17000758 MGI
Cellular Component GO Annotation Evidence References Source
located in lamellipodium IDA
IDA: Inferred from direct assay
12637522 MGI
located in membrane IDA
IDA: Inferred from direct assay
12637522 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide exchange factor DBS

  • DBL's big sister

  • MCF2-transforming sequence-like protein

  • Ost gamma

  • exchange factor for RhoA and Cdc42

  • guanine nucleotide exchange factor OSTIII

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08223 MCF2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22629 Mcf2l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcf2l NCBI NCBI:23263