Mesp2 - mesoderm posterior 2 Gene

Also Known as bHLHc6

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17293

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesodermal cell migration; regulation of gene expression; and somite rostral/caudal axis specification. Located in nucleus. Is expressed in several structures, including central nervous system; ear; embryo mesoderm; genitourinary system; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Mesp2 Products (1)

mRNA	Protein	Name
NM_008589.2	NP_032615.2	mesoderm posterior protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15902259	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15902259	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15902259	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	15902259	MGI
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	20346937	MGI
acts upstream of or within mesodermal cell migration	IGI IGI: Inferred from genetic interaction	10887078	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15902259	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15902259	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20346937	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	20346937	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	15902259	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	15902259	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15902259	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mesoderm posterior protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08343	MESP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mesp2	NCBI	NCBI:145873