Afdn - afadin, adherens junction formation factor Gene

Also Known as AF6; Af-6; Gm314; Mllt4; Afadin; I-afadin; S-afadin; 5033403D15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17356

Summary

Enables cell adhesion molecule binding activity. Involved in cell-cell adhesion mediated by cadherin; establishment of protein localization to plasma membrane; and pore complex assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]

Afdn Products (1)

mRNA Protein Name
NM_010806.1 NP_034936.1 afadin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
10225955 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12446711 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adherens junction maintenance IMP
IMP: Inferred from mutant phenotype
25100583 MGI
acts upstream of or within brain morphogenesis IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in cell-cell adhesion mediated by cadherin IMP
IMP: Inferred from mutant phenotype
23990464 MGI
acts upstream of or within cerebral cortex development IGI
IGI: Inferred from genetic interaction
25100583 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
25100583 MGI
involved in establishment of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23990464 MGI
acts upstream of or within homeostasis of number of cells IGI
IGI: Inferred from genetic interaction
25100583 MGI
acts upstream of or within neuroepithelial cell differentiation IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in pore complex assembly IMP
IMP: Inferred from mutant phenotype
30463011 MGI
acts upstream of or within protein localization to cell junction IMP
IMP: Inferred from mutant phenotype
22512338 MGI
acts upstream of or within radial glial cell differentiation IGI
IGI: Inferred from genetic interaction
25100583 MGI
acts upstream of or within regulation of oligodendrocyte progenitor proliferation IGI
IGI: Inferred from genetic interaction
25100583 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
29969655 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
29969655 MGI
acts upstream of or within telencephalon development IGI
IGI: Inferred from genetic interaction
25100583 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
11731229 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
22512338 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
10704870 MGI
located in cell junction IDA
IDA: Inferred from direct assay
15509704 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
18604197 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15509704 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
11827984 MGI
part of pore complex IMP
IMP: Inferred from mutant phenotype
30463011 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
11827984 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11827984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

afadin

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

  • translocated to, 4

  • myeloid/lymphoid or mixed-lineage leukemia

  • translocated to, 4

  • protein Af-6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00427 AFDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Afdn NCBI NCBI:4301