Ndst2 - N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Gene

Also Known as Mndns; NDST-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17423

Summary

Enables deacetylase activity and sulfotransferase activity. Acts upstream of or within heparan sulfate proteoglycan biosynthetic process; mast cell mediated immunity; and regulation of angiotensin levels in blood. Located in Golgi apparatus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ndst2 Products (1)

mRNA Protein Name
NM_010811.2 NP_034941.2 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosamine deacetylase activity IDA
IDA: Inferred from direct assay
8294485 MGI
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
IDA: Inferred from direct assay
8294485 MGI
enables deacetylase activity IDA
IDA: Inferred from direct assay
11087757 MGI
enables heparan sulfate N-deacetylase activity IDA
IDA: Inferred from direct assay
10758005 MGI
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
11087757 MGI
Biological Process GO Annotation Evidence References Source
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
8294485 MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
10466727 MGI
involved in heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
30377379 MGI
involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
IDA: Inferred from direct assay
10758005 MGI
acts upstream of or within mast cell mediated immunity IMP
IMP: Inferred from mutant phenotype
10466726 MGI
acts upstream of or within regulation of angiotensin levels in blood IMP
IMP: Inferred from mutant phenotype
15173164 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
8294485 MGI
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10639137 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

  • N-HSST 2

  • N-heparan sulfate sulfotransferase 2

  • [Heparan sulfate]-glucosamine N-sulfotransferase

  • glucosaminyl N-deacetylase/N-sulfotransferase 2

  • glucosaminyl N-deacetylase/N-sulphotransferase 2

  • heparan N-sulfotransferase 2

  • heparan glucosaminyl N-deace

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09119 NDST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndst2 NCBI NCBI:8509