Ndst2 - N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Gene

Mus musculus

Also known as Mndns; NDST-2

Gene ID: 17423 | Gene type: protein coding

About Ndst2

Summary

Enables deacetylase activity and sulfotransferase activity. Acts upstream of or within heparan sulfate proteoglycan biosynthetic process; mast cell mediated immunity; and regulation of angiotensin levels in blood. Located in Golgi apparatus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ndst2 Products(1)

mRNA	Protein	Name
NM_010811.2	NP_034941.2	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acetylglucosamine deacetylase activity	IDA IDA: Inferred from direct assay	8294485	MGI
enables [heparan sulfate]-glucosamine N-sulfotransferase activity	IDA IDA: Inferred from direct assay	8294485	MGI
enables deacetylase activity	IDA IDA: Inferred from direct assay	11087757	MGI
enables heparan sulfate N-deacetylase activity	IDA IDA: Inferred from direct assay	10758005	MGI
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	11087757	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in heparan sulfate proteoglycan biosynthetic process	IDA IDA: Inferred from direct assay	8294485	MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	10466727	MGI
involved in heparan sulfate proteoglycan biosynthetic process	IMP IMP: Inferred from mutant phenotype	30377379	MGI
involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IDA IDA: Inferred from direct assay	10758005	MGI
acts upstream of or within mast cell mediated immunity	IMP IMP: Inferred from mutant phenotype	10466726	MGI
acts upstream of or within regulation of angiotensin levels in blood	IMP IMP: Inferred from mutant phenotype	15173164	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	8294485	MGI
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10639137	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

N-HSST 2	N-heparan sulfate sulfotransferase 2
[Heparan sulfate]-glucosamine N-sulfotransferase	glucosaminyl N-deacetylase/N-sulfotransferase 2
glucosaminyl N-deacetylase/N-sulphotransferase 2	heparan N-sulfotransferase 2
heparan glucosaminyl N-deace

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09119	NDST2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ndst2	NCBI	NCBI:8509

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