Meis3 - Meis homeobox 3 Gene

Also Known as Mrg2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17537

Summary

The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Meis3 Products (4)

mRNA Protein Name
NM_001277988.2 NP_001264917.1 homeobox protein Meis3 isoform b
NM_001277989.2 NP_001264918.1 homeobox protein Meis3 isoform b
NM_001302472.1 NP_001289401.1 homeobox protein Meis3 isoform a
NM_008627.4 NP_032653.2 homeobox protein Meis3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21059917 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
21059917 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21059917 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
21059917 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21059917 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Meis3

  • meis1-related protein 2

  • myeloid ecotropic viral integration site-related gene 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08327 MEIS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Meis3 NCBI NCBI:56917