Msh3 - mutS homolog 3 Gene

Also Known as Rep3; REP-1; Rep-3; D13Em1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17686

Summary

Enables centromeric DNA binding activity and damaged DNA binding activity. Acts upstream of or within mismatch repair and somatic recombination of immunoglobulin gene segments. Predicted to be located in nucleus. Predicted to be part of MutSbeta complex. Is expressed in early conceptus; oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3). [provided by Alliance of Genome Resources, Apr 2022]

Msh3 Products (2)

mRNA Protein Name
NM_001311120.2 NP_001298049.1 DNA mismatch repair protein Msh3 isoform 2
NM_010829.3 NP_034959.2 DNA mismatch repair protein Msh3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IGI
IGI: Inferred from genetic interaction
10545954 MGI
enables centromeric DNA binding IDA
IDA: Inferred from direct assay
16260499 MGI
enables damaged DNA binding IGI
IGI: Inferred from genetic interaction
10545954 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mismatch repair IGI
IGI: Inferred from genetic interaction
10706084 MGI
acts upstream of or within mismatch repair IMP
IMP: Inferred from mutant phenotype
10706084 MGI
NOT acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
10662804 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: Inferred from mutant phenotype
15238604 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA mismatch repair protein Msh3

  • protein repair-1

  • protein repair-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08710 MSH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Msh3 NCBI NCBI:4437