Msh5 - mutS homolog 5 Gene

Mus musculus

Also known as Mut5

Gene ID: 17687 | Gene type: protein coding

About Msh5

Summary

This gene encodes a member of the MutS family of proteins that play critical roles in DNA mismatch repair and meiotic homologous recombination processes. Mice lacking the encoded protein are viable but sterile, with severe defects in spermatogenesis in males and complete loss of ovarian structures in females. Mutations in a similar gene in humans have been shown to cause common variable immune deficiency (CVID) and immunoglobulin A deficiency. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Msh5 Products(2)

mRNA	Protein	Name
NM_001146215.2	NP_001139687.1	mutS protein homolog 5
NM_013600.3	NP_038628.2	mutS protein homolog 5

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within female gamete generation	IMP IMP: Inferred from mutant phenotype	15640358	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	10809667	MGI
acts upstream of or within meiosis I	IMP IMP: Inferred from mutant phenotype	10809667	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in synaptonemal complex	IDA IDA: Inferred from direct assay	16260499	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mutS protein homolog 5

DNA mismatch repair protein Msh5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08712	MSH5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Msh5	NCBI	NCBI:4439

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