Mvk - mevalonate kinase Gene

Also Known as MK; 2310010A05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17855

Summary

This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of Cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Mvk Products (4)

mRNA Protein Name
NM_001306205.1 NP_001293134.1 mevalonate kinase isoform 1
NM_023556.3 NP_076045.1 mevalonate kinase isoform 2
NM_001306205.1 NP_001293134.1 mevalonate kinase isoform 1
NM_023556.3 NP_076045.1 mevalonate kinase isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables mevalonate kinase activity IDA
IDA: Inferred from direct assay
11792727 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mevalonate kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08857 MVK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18739 Mvk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25226 Mvk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mvk NCBI NCBI:4598