Myh6 - myosin, heavy polypeptide 6, cardiac muscle, alpha Gene

Also Known as Myhca; Myhc-a; alphaMHC; alpha-MHC; A830009F23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17888

Summary

Enables microfilament motor activity. Involved in cardiac muscle contraction. Acts upstream of or within several processes, including adult heart development; muscle cell development; and regulation of heart contraction. Located in Z disc and stress fiber. Part of Myosin complex. Is expressed in several structures, including brown fat; embryo mesenchyme; great vessel of heart; heart; and skeletal musculature. Used to study dilated cardiomyopathy; dilated cardiomyopathy 1EE; and hypertrophic cardiomyopathy 14. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (Myosin heavy chain 6). [provided by Alliance of Genome Resources, Apr 2022]

Myh6 Products (2)

mRNA Protein Name
NM_001164171.1 NP_001157643.1 myosin-6
NM_010856.4 NP_034986.1 myosin-6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microfilament motor activity IMP
IMP: Inferred from mutant phenotype
15001446 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17075052 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament-based movement IMP
IMP: Inferred from mutant phenotype
15001446 MGI
acts upstream of or within adult heart development IMP
IMP: Inferred from mutant phenotype
8878443 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
8878443 MGI
involved in cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
9884344 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
24137001 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
8878443 MGI
acts upstream of or within myofibril assembly IMP
IMP: Inferred from mutant phenotype
8878443 MGI
acts upstream of or within regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
15001446 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
8878443 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
8614836 MGI
acts upstream of or within regulation of heart growth IDA
IDA: Inferred from direct assay
17379774 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
9541509 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
9541509 MGI
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
8878443 MGI
acts upstream of or within striated muscle contraction IMP
IMP: Inferred from mutant phenotype
8614836 MGI
acts upstream of or within visceral muscle development IMP
IMP: Inferred from mutant phenotype
11708849 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
21126233 MGI
located in myofibril IDA
IDA: Inferred from direct assay
8878443 MGI
part of myosin complex IDA
IDA: Inferred from direct assay
8482409 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
21126233 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-6

  • alpha cardiac MHC

  • alpha myosin

  • cardiomyopathy, hypertrophic 1

  • myHC-alpha

  • myosin heavy chain 6

  • myosin heavy chain, cardiac muscle, adult

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08904 MYH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21384 Myh6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27903 Myh6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh6 NCBI NCBI:4624