2. Gene
  3. Myl2 - myosin, light polypeptide 2, regulatory, cardiac, slow Gene

Myl2 - myosin, light polypeptide 2, regulatory, cardiac, slow Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MLC-2; Mlc2v; Mylpc; MLC-2v; Gm32672; MLC-2s/v

Gene ID: 17906 | Gene type: protein coding

About Myl2

Summary

Predicted to enable actin monomer binding activity and calcium ion binding activity. Involved in heart development and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including cardiac muscle contraction; heart development; and muscle cell fate specification. Located in myofibril. Is expressed in several structures, including diaphragm; embryo mesoderm; eye; heart; and triceps surae muscle. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 10. Orthologous to human MYL2 (Myosin light chain 2). [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cardiac muscle contraction IGI
IGI: Inferred from genetic interaction
15308581 MGI
acts upstream of or within cardiac myofibril assembly IMP
IMP: Inferred from mutant phenotype
9422794 MGI
acts upstream of or within heart contraction IDA
IDA: Inferred from direct assay
8777429 MGI
involved in heart contraction IDA
IDA: Inferred from direct assay
10409661 MGI
involved in heart development IDA
IDA: Inferred from direct assay
10409661 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
9422794 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
15308581 MGI
acts upstream of or within muscle cell development IGI
IGI: Inferred from genetic interaction
15308581 MGI
acts upstream of or within muscle cell fate specification IMP
IMP: Inferred from mutant phenotype
1379240 MGI
involved in positive regulation of the force of heart contraction IDA
IDA: Inferred from direct assay
16908724 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
15308581 MGI
Cellular Component GO Annotation Evidence Reference Source
located in myofibril IDA
IDA: Inferred from direct assay
11356630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin regulatory light chain 2, ventricular/cardiac muscle isoform

myosin light chain 2v

myosin light chain, phosphorylatable, cardiac ventricles

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08914 MYL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myl2 NCBI NCBI:4633