2. Gene
  3. Myo6 - myosin VI Gene

Myo6 - myosin VI Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as sv; Tlc; rsv; Myo6

Gene ID: 17920 | Gene type: protein coding

About Myo6

Summary

Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; cochlear hair cell ribbon synapse; and glutamatergic synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic density. Is expressed in ear. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (Myosin VI). [provided by Alliance of Genome Resources, Apr 2022]

Myo6 Products(8)

mRNA Protein Name
NM_001039546.3 NP_001034635.2 unconventional myosin-VI isoform 3
NM_001408252.1 NP_001395181.1 unconventional myosin-VI isoform 1
NM_001408253.1 NP_001395182.1 unconventional myosin-VI isoform 2
NM_001408255.1 NP_001395184.1 unconventional myosin-VI isoform 4
NM_001039546.3 NP_001034635.2 unconventional myosin-VI isoform 3
NM_001408252.1 NP_001395181.1 unconventional myosin-VI isoform 1
NM_001408253.1 NP_001395182.1 unconventional myosin-VI isoform 2
NM_001408255.1 NP_001395184.1 unconventional myosin-VI isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15975910 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16819522 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
15657400 MGI
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
15657400 MGI
acts upstream of or within glutamate secretion IMP
IMP: Inferred from mutant phenotype
16819522 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
5980120 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
5980120 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
7493015 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
16962269 MGI
involved in postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
15657400 MGI
involved in postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
15657400 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
16819522 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16819522 MGI
involved in protein localization IMP
IMP: Inferred from mutant phenotype
24285636 MGI
acts upstream of or within protein targeting IPI
IPI: Inferred from physical interaction
15975910 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
16819522 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
5980120 MGI
acts upstream of or within synapse assembly IMP
IMP: Inferred from mutant phenotype
15657400 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
16819522 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
16819522 MGI
located in axon IDA
IDA: Inferred from direct assay
16819522 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
is active in cochlear hair cell ribbon synapse IDA
IDA: Inferred from direct assay
19744958 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20016102 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15657400 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
15657400 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15657400 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16819522 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22105175 MGI
located in plasma membrane IPI
IPI: Inferred from physical interaction
15975910 MGI
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
15657400 MGI
is active in postsynaptic actin cytoskeleton IEP
IEP: Inferred from expression pattern
15657400 MGI
is active in postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
15657400 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15657400 MGI
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
15657400 MGI
is active in presynaptic endocytic zone IDA
IDA: Inferred from direct assay
19744958 MGI
located in vesicle membrane IPI
IPI: Inferred from physical interaction
15975910 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-VI

Snell's waltzer

protein twist

tailchaser

unconventional myosin-6

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08949 MYO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo6 NCBI NCBI:4646