Myo7a - myosin VIIA Gene

Mus musculus

Also known as Hdb; sh1; Myo7; sh-1; USH1B; polka; nmf371

Gene ID: 17921 | Gene type: protein coding

About Myo7a

Summary

Enables protein domain specific binding activity. Involved in cellular protein localization. Acts upstream of or within several processes, including animal organ morphogenesis; phagolysosome assembly; and pigment granule transport. Located in several cellular components, including melanosome; photoreceptor connecting cilium; and stereocilium base. Is active in stereocilium. Is expressed in central nervous system; liver; sensory organ; and small intestine epithelium. Used to study Usher syndrome type 1 and autosomal recessive nonsyndromic deafness 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (Myosin VIIA). [provided by Alliance of Genome Resources, Apr 2022]

Myo7a Products(4)

mRNA	Protein	Name
NM_001256081.1	NP_001243010.1	unconventional myosin-VIIa isoform 1
NM_001256082.1	NP_001243011.1	unconventional myosin-VIIa isoform 3
NM_001256083.1	NP_001243012.1	unconventional myosin-VIIa isoform 4
NM_008663.2	NP_032689.2	unconventional myosin-VIIa isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12485990	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17666436	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	11753415	MGI
acts upstream of or within cell projection organization	IMP IMP: Inferred from mutant phenotype	9435277	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	6627025	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	11753415	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	6627025	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	5795329	MGI
acts upstream of or within inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	9435277	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	18339676	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	10414956	MGI
acts upstream of or within mechanoreceptor differentiation	IMP IMP: Inferred from mutant phenotype	17567809	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	12743369	MGI
acts upstream of or within phagolysosome assembly	IMP IMP: Inferred from mutant phenotype	12743369	MGI
acts upstream of or within pigment granule localization	IMP IMP: Inferred from mutant phenotype	14609561	MGI
acts upstream of or within pigment granule transport	IMP IMP: Inferred from mutant phenotype	9620764	MGI
involved in protein localization	IDA IDA: Inferred from direct assay	27525485	MGI
acts upstream of or within sensory perception	IMP IMP: Inferred from mutant phenotype	11162241	MGI
acts upstream of or within sensory perception of light stimulus	IMP IMP: Inferred from mutant phenotype	14609561	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	6627025	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	11222540	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	9620764	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11023859	MGI
located in melanosome	IDA IDA: Inferred from direct assay	14978221	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	10414956	MGI
NOT located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	8842737	MGI
NOT located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	8842737	MGI
is active in stereocilium	EXP EXP: Inferred from Experiment	26754646	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	12485990	MGI
located in stereocilium base	IDA IDA: Inferred from direct assay	17567809	MGI
NOT located in synapse	IDA IDA: Inferred from direct assay	8842737	MGI
located in synapse	IDA IDA: Inferred from direct assay	11964381	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-VIIa

motor protein	myosin-VIIa
shaker 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08950	MYO7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo7a	NCBI	NCBI:4647

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