Ndn - necdin, MAGE family member Gene

Mus musculus

Also known as Peg6

Gene ID: 17984 | Gene type: protein coding

About Ndn

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; gamma-tubulin binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including nervous system development; neurotrophin Trk Receptor signaling pathway; and regulation of transcription, DNA-templated. Located in several cellular components, including centrosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to human NDN (necdin, MAGE family member). [provided by Alliance of Genome Resources, Apr 2022]

Ndn Products(1)

mRNA	Protein	Name
NM_010882.3	NP_035012.2	necdin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	15649943	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22514318	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12198120	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	15972963	MGI
acts upstream of or within axonal fasciculation	IMP IMP: Inferred from mutant phenotype	15972963	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	15649943	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	15649943	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	10508517	MGI
acts upstream of or within glial cell migration	IMP IMP: Inferred from mutant phenotype	15972963	MGI
acts upstream of or within multicellular organismal-level homeostasis	IMP IMP: Inferred from mutant phenotype	10508517	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12198120	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22514318	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22514318	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	16049186	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	12198120	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15972963	MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16049186	MGI
acts upstream of or within positive regulation of protein deacetylation	IDA IDA: Inferred from direct assay	22514318	MGI
acts upstream of or within positive regulation of protein deacetylation	IMP IMP: Inferred from mutant phenotype	22514318	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24349431	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	10508517	MGI
acts upstream of or within regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	14593116	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	12629158	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	10508517	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16049186	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	10965153	MGI
located in centrosome	IDA IDA: Inferred from direct assay	15649943	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10965153	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10965153	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14593116	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	22514318	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

necdin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09110	NDN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ndn	NCBI	NCBI:4692

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