Ndn - necdin, MAGE family member Gene

Also Known as Peg6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17984

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; gamma-tubulin binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including nervous system development; neurotrophin Trk Receptor signaling pathway; and regulation of transcription, DNA-templated. Located in several cellular components, including centrosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to human NDN (necdin, MAGE family member). [provided by Alliance of Genome Resources, Apr 2022]

Ndn Products (1)

mRNA Protein Name
NM_010882.3 NP_035012.2 necdin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gamma-tubulin binding IDA
IDA: Inferred from direct assay
15649943 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22514318 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12198120 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon extension IMP
IMP: Inferred from mutant phenotype
15972963 MGI
acts upstream of or within axonal fasciculation IMP
IMP: Inferred from mutant phenotype
15972963 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
15649943 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
15649943 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
10508517 MGI
acts upstream of or within glial cell migration IMP
IMP: Inferred from mutant phenotype
15972963 MGI
acts upstream of or within multicellular organismal-level homeostasis IMP
IMP: Inferred from mutant phenotype
10508517 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12198120 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
22514318 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22514318 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
16049186 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
12198120 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15972963 MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16049186 MGI
acts upstream of or within positive regulation of protein deacetylation IDA
IDA: Inferred from direct assay
22514318 MGI
acts upstream of or within positive regulation of protein deacetylation IMP
IMP: Inferred from mutant phenotype
22514318 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24349431 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
10508517 MGI
acts upstream of or within regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
14593116 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
12629158 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
10508517 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16049186 MGI
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
10965153 MGI
located in centrosome IDA
IDA: Inferred from direct assay
15649943 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10965153 MGI
located in cytosol IDA
IDA: Inferred from direct assay
10965153 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14593116 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
22514318 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

necdin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09110 NDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndn NCBI NCBI:4692