2. Gene
  3. Ndufa2 - NADH:ubiquinone oxidoreductase subunit A2 Gene

Ndufa2 - NADH:ubiquinone oxidoreductase subunit A2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B8; C1-B8; CI-B8

Gene ID: 17991 | Gene type: protein coding

About Ndufa2

Summary

This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013]

Ndufa2 Products(1)

mRNA Protein Name
NM_010885.5 NP_035015.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
27869233 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2

NADH-ubiquinone oxidoreductase B8 subunit

complex I-B8

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09127 NDUFA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufa2 NCBI NCBI:4695