Neurod2 - neurogenic differentiation 2 Gene

Mus musculus

Also known as Ndrf; bHLHa1

Gene ID: 18013 | Gene type: protein coding

About Neurod2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to electrical stimulus; regulation of synapse maturation; and regulation of transcription, DNA-templated. Acts upstream of or within associative learning; behavioral fear response; and neuron development. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2). [provided by Alliance of Genome Resources, Apr 2022]

Neurod2 Products(1)

mRNA	Protein	Name
NM_010895.3	NP_035025.3	neurogenic differentiation factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16203979	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10098882	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20346398	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	14697366	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10098882	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18214987	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	18214987	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	16203979	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	16203979	MGI
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	16504944	MGI
involved in cellular response to electrical stimulus	IDA IDA: Inferred from direct assay	16504944	MGI
involved in cerebellar cortex development	IMP IMP: Inferred from mutant phenotype	16504944	MGI
involved in negative regulation of synapse maturation	IDA IDA: Inferred from direct assay	19900895	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	16203979	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14697366	MGI
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	16504944	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10648228	MGI
involved in positive regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	16504944	MGI
involved in positive regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	19900895	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10098882	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19900895	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10648228	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurogenic differentiation factor 2

neuroD-related factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09225	NEUROD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174572	Human NEUROD2 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Neurod2	NCBI	NCBI:4761

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