Neurod2 - neurogenic differentiation 2 Gene

Also Known as Ndrf; bHLHa1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18013

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to electrical stimulus; regulation of synapse maturation; and regulation of transcription, DNA-templated. Acts upstream of or within associative learning; behavioral fear response; and neuron development. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2). [provided by Alliance of Genome Resources, Apr 2022]

Neurod2 Products (1)

mRNA Protein Name
NM_010895.3 NP_035025.3 neurogenic differentiation factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16203979 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10098882 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20346398 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
14697366 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10098882 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18214987 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
18214987 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
16203979 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
16203979 MGI
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
16504944 MGI
involved in cellular response to electrical stimulus IDA
IDA: Inferred from direct assay
16504944 MGI
involved in cerebellar cortex development IMP
IMP: Inferred from mutant phenotype
16504944 MGI
involved in negative regulation of synapse maturation IDA
IDA: Inferred from direct assay
19900895 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
16203979 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14697366 MGI
involved in positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
16504944 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10648228 MGI
involved in positive regulation of synapse maturation IMP
IMP: Inferred from mutant phenotype
16504944 MGI
involved in positive regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
19900895 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10098882 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19900895 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10648228 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenic differentiation factor 2

  • neuroD-related factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09225 NEUROD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174572 Human NEUROD2 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Neurod2 NCBI NCBI:4761