Nfatc3 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Gene

Mus musculus

Also known as NFAT4; NFATx; D8Ertd281e

Gene ID: 18021 | Gene type: protein coding

About Nfatc3

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; branching involved in blood vessel morphogenesis; and cellular response to metal ion. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human NFATC3 (nuclear factor of activated T cells 3). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc3 Products(3)

mRNA	Protein	Name
NM_001368796.1	NP_001355725.1	nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
NM_001368797.1	NP_001355726.1	nuclear factor of activated T-cells, cytoplasmic 3 isoform 3
NM_010901.3	NP_035031.2	nuclear factor of activated T-cells, cytoplasmic 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16260608	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21514407	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16260608	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16998587	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16260608	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7650004	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19538478	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	18676376	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DN4 thymocyte differentiation	IMP IMP: Inferred from mutant phenotype	17579027	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	9768749	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	17403661	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	11439183	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	18676376	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IGI IGI: Inferred from genetic interaction	12370307	MGI
acts upstream of or within cellular respiration	IMP IMP: Inferred from mutant phenotype	12750314	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	23219532	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	20530871	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	12750314	MGI
acts upstream of or within myotube cell development	IMP IMP: Inferred from mutant phenotype	18676376	MGI
acts upstream of or within myotube differentiation	IMP IMP: Inferred from mutant phenotype	23206701	MGI
involved in positive regulation of artery morphogenesis	IMP IMP: Inferred from mutant phenotype	20495147	MGI
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	24970700	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10755616	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19538478	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16998587	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20495147	MGI
involved in positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	17579027	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16260608	MGI
acts upstream of or within regulation of store-operated calcium entry	IMP IMP: Inferred from mutant phenotype	23206701	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	17403661	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	11254352	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	9768749	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24301466	MGI
acts upstream of or within vascular associated smooth muscle cell development	IGI IGI: Inferred from genetic interaction	11439183	MGI
acts upstream of or within vascular associated smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	11439183	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9017603	MGI
located in cytosol	IDA IDA: Inferred from direct assay	20530871	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9017603	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 3

NF-AT4	NF-ATc3
T-cell transcription factor NFAT4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1353	Rhamnocitrin	Inhibitor	99.67%	Unkown
HY-P10889	CNI103	Inhibitor	99.56%	Unkown
HY-RS09241	NFATC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfatc3	NCBI	NCBI:4775

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