Nfatc3 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Gene

Also Known as NFAT4; NFATx; D8Ertd281e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18021

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; branching involved in blood vessel morphogenesis; and cellular response to metal ion. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human NFATC3 (nuclear factor of activated T cells 3). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc3 Products (3)

mRNA Protein Name
NM_001368796.1 NP_001355725.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
NM_001368797.1 NP_001355726.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 3
NM_010901.3 NP_035031.2 nuclear factor of activated T-cells, cytoplasmic 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16260608 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21514407 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16260608 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16998587 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16260608 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7650004 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19538478 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
18676376 MGI
Biological Process GO Annotation Evidence References Source
involved in DN4 thymocyte differentiation IMP
IMP: Inferred from mutant phenotype
17579027 MGI
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
9768749 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
17403661 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
11439183 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IGI
IGI: Inferred from genetic interaction
18676376 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IGI
IGI: Inferred from genetic interaction
12370307 MGI
acts upstream of or within cellular respiration IMP
IMP: Inferred from mutant phenotype
12750314 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
23219532 MGI
acts upstream of or within cellular response to lithium ion IDA
IDA: Inferred from direct assay
20530871 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
12750314 MGI
acts upstream of or within myotube cell development IMP
IMP: Inferred from mutant phenotype
18676376 MGI
acts upstream of or within myotube differentiation IMP
IMP: Inferred from mutant phenotype
23206701 MGI
involved in positive regulation of artery morphogenesis IMP
IMP: Inferred from mutant phenotype
20495147 MGI
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
24970700 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10755616 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19538478 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16998587 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20495147 MGI
involved in positive thymic T cell selection IMP
IMP: Inferred from mutant phenotype
17579027 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16260608 MGI
acts upstream of or within regulation of store-operated calcium entry IMP
IMP: Inferred from mutant phenotype
23206701 MGI
acts upstream of or within response to hypoxia IDA
IDA: Inferred from direct assay
17403661 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
11254352 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
9768749 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24301466 MGI
acts upstream of or within vascular associated smooth muscle cell development IGI
IGI: Inferred from genetic interaction
11439183 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
11439183 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9017603 MGI
located in cytosol IDA
IDA: Inferred from direct assay
20530871 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9017603 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 3

  • NF-AT4

  • NF-ATc3

  • T-cell transcription factor NFAT4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1353 Rhamnocitrin Inhibitor 99.67% Unkown
HY-P10889 CNI103 Inhibitor 99.56% Unkown
HY-RS09241 NFATC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfatc3 NCBI NCBI:4775