Nfia - nuclear factor I/A Gene

Also Known as CTF; NF1A; NF1-A; 1110047K16Rik; 9430022M17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18027

Summary

Enables DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within synapse maturation and ureter development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in NFIA-related disorder. Orthologous to human NFIA (nuclear factor I A). [provided by Alliance of Genome Resources, Apr 2022]

Nfia Products (3)

mRNA Protein Name
NM_001122952.1 NP_001116424.1 nuclear factor 1 A-type isoform 1
NM_001122953.1 NP_001116425.1 nuclear factor 1 A-type isoform 3
NM_010905.3 NP_035035.1 nuclear factor 1 A-type isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12955085 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
23407945 MGI
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
29247144 MGI
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
29247144 MGI
involved in cell morphogenesis IMP
IMP: Inferred from mutant phenotype
29247144 MGI
acts upstream of or within cell quiescence IMP
IMP: Inferred from mutant phenotype
33004674 MGI
acts upstream of or within exit from mitosis IMP
IMP: Inferred from mutant phenotype
31128945 MGI
involved in gene expression IGI
IGI: Inferred from genetic interaction
29106906 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
31128945 MGI
acts upstream of or within generation of neurons IMP
IMP: Inferred from mutant phenotype
33004674 MGI
acts upstream of or within glial cell fate specification IMP
IMP: Inferred from mutant phenotype
31128945 MGI
acts upstream of or within glial cell proliferation IMP
IMP: Inferred from mutant phenotype
31128945 MGI
involved in limb morphogenesis IMP
IMP: Inferred from mutant phenotype
29247144 MGI
acts upstream of or within neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
31128945 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
31128945 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
31128945 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9056636 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19706729 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
33004674 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
31128945 MGI
acts upstream of or within synapse maturation IMP
IMP: Inferred from mutant phenotype
23407945 MGI
acts upstream of or within ureter development IMP
IMP: Inferred from mutant phenotype
17530927 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8306889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor 1 A-type

  • CCAAT-box-binding transcription factor

  • TGGCA-binding protein

  • nuclear factor 1/A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09249 NFIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20782 Nfia Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27296 Nfia Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfia NCBI NCBI:4774