Nkx2-2 - NK2 homeobox 2 Gene

Also Known as Nkx2.2; tinman; Nkx-2.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18088

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including enteroendocrine cell differentiation; neurogenesis; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural ectoderm; and sensory organ. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-2 Products (4)

mRNA Protein Name
NM_001077632.1 NP_001071100.1 homeobox protein Nkx-2.2 isoform 2
NM_010919.2 NP_035049.1 homeobox protein Nkx-2.2 isoform 1
NM_001077632.1 NP_001071100.1 homeobox protein Nkx-2.2 isoform 2
NM_010919.2 NP_035049.1 homeobox protein Nkx-2.2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19759004 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14573534 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19759004 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14573534 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14701942 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
16887115 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19258013 MGI
acts upstream of or within cell development IMP
IMP: Inferred from mutant phenotype
11526078 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
14970313 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
18987169 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
9584121 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10217145 MGI
acts upstream of or within nervous system development IDA
IDA: Inferred from direct assay
14573534 MGI
acts upstream of or within neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
18987169 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10217145 MGI
acts upstream of or within neuron fate specification IGI
IGI: Inferred from genetic interaction
16339193 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
19592574 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
11526078 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
11566099 MGI
acts upstream of or within pancreatic A cell fate commitment IGI
IGI: Inferred from genetic interaction
17988662 MGI
acts upstream of or within pancreatic A cell fate commitment IMP
IMP: Inferred from mutant phenotype
17202186 MGI
acts upstream of or within pancreatic PP cell fate commitment IGI
IGI: Inferred from genetic interaction
17988662 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
14729487 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
24101522 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
acts upstream of or within positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10217145 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
11566099 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11526078 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14573534 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
10217145 MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation IGI
IGI: Inferred from genetic interaction
18287202 MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation IMP
IMP: Inferred from mutant phenotype
11526078 MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification IDA
IDA: Inferred from direct assay
18287202 MGI
acts upstream of or within type B pancreatic cell development IDA
IDA: Inferred from direct assay
17456846 MGI
acts upstream of or within type B pancreatic cell development IMP
IMP: Inferred from mutant phenotype
17202186 MGI
acts upstream of type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
14729487 MGI
acts upstream of or within type B pancreatic cell fate commitment IMP
IMP: Inferred from mutant phenotype
17202186 MGI
acts upstream of or within ventral spinal cord interneuron fate determination IMP
IMP: Inferred from mutant phenotype
10217145 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
15793245 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9230312 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-2.2

  • Drosophila NK2 transcription factor related, locus 2

  • NK2 transcription factor related, locus 2

  • glycoprotein GP330, renal

  • homeobox protein NK-2 homolog B

  • homeobox protein Nkx2-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09328 NKX2-2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx2-2 NCBI NCBI:4821