Nkx2-2 - NK2 homeobox 2 Gene

Mus musculus

Also known as Nkx2.2; tinman; Nkx-2.2

Gene ID: 18088 | Gene type: protein coding

About Nkx2-2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including enteroendocrine cell differentiation; neurogenesis; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural ectoderm; and sensory organ. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-2 Products(4)

mRNA	Protein	Name
NM_001077632.1	NP_001071100.1	homeobox protein Nkx-2.2 isoform 2
NM_010919.2	NP_035049.1	homeobox protein Nkx-2.2 isoform 1
NM_001077632.1	NP_001071100.1	homeobox protein Nkx-2.2 isoform 2
NM_010919.2	NP_035049.1	homeobox protein Nkx-2.2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19759004	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14573534	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19759004	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14573534	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14701942	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	16887115	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19258013	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	11526078	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	14970313	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	18987169	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	9584121	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10830170	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10217145	MGI
acts upstream of or within nervous system development	IDA IDA: Inferred from direct assay	14573534	MGI
acts upstream of or within neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	18987169	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	10830170	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10217145	MGI
acts upstream of or within neuron fate specification	IGI IGI: Inferred from genetic interaction	16339193	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	19592574	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	11526078	MGI
acts upstream of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	11566099	MGI
acts upstream of or within pancreatic A cell fate commitment	IGI IGI: Inferred from genetic interaction	17988662	MGI
acts upstream of or within pancreatic A cell fate commitment	IMP IMP: Inferred from mutant phenotype	17202186	MGI
acts upstream of or within pancreatic PP cell fate commitment	IGI IGI: Inferred from genetic interaction	17988662	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	14729487	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	24101522	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10830170	MGI
acts upstream of or within positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10217145	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	11566099	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11526078	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14573534	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	18590716	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	10217145	MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation	IGI IGI: Inferred from genetic interaction	18287202	MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation	IMP IMP: Inferred from mutant phenotype	11526078	MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification	IDA IDA: Inferred from direct assay	18287202	MGI
acts upstream of or within type B pancreatic cell development	IDA IDA: Inferred from direct assay	17456846	MGI
acts upstream of or within type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	17202186	MGI
acts upstream of type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	14729487	MGI
acts upstream of or within type B pancreatic cell fate commitment	IMP IMP: Inferred from mutant phenotype	17202186	MGI
acts upstream of or within ventral spinal cord interneuron fate determination	IMP IMP: Inferred from mutant phenotype	10217145	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	15793245	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9230312	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-2.2

Drosophila NK2 transcription factor related, locus 2	NK2 transcription factor related, locus 2
glycoprotein GP330, renal	homeobox protein NK-2 homolog B
homeobox protein Nkx2-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09328	NKX2-2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx2-2	NCBI	NCBI:4821

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