Nkx2-3 - NK2 homeobox 3 Gene

Also Known as Nkx2.3; nkx2-C; tinman; Nkx-2.3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18089

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ morphogenesis; hematopoietic or lymphoid organ development; and post-embryonic digestive tract morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo mesoderm; and spleen. Orthologous to human NKX2-3 (NK2 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-3 Products (2)

mRNA Protein Name
NM_008699.2 NP_032725.1 homeobox protein Nkx-2.3
NM_008699.2 NP_032725.1 homeobox protein Nkx-2.3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
12682228 MGI
acts upstream of or within CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within Peyer's patch development IMP
IMP: Inferred from mutant phenotype
10790368 MGI
acts upstream of or within cell fate specification IMP
IMP: Inferred from mutant phenotype
38311164 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
10207146 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
38311164 MGI
acts upstream of or within gland morphogenesis IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
12682228 MGI
acts upstream of or within leukocyte homeostasis IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within leukocyte migration IMP
IMP: Inferred from mutant phenotype
10790368 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
10790368 MGI
acts upstream of or within macrophage differentiation IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within mucosa-associated lymphoid tissue development IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
12141427 MGI
acts upstream of or within plasma cell differentiation IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10790368 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within post-embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10207146 MGI
acts upstream of or within saliva secretion IMP
IMP: Inferred from mutant phenotype
38311164 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
10207146 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10926756 MGI
acts upstream of or within triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
10926756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-2.3

  • NK2 transcription factor related, locus 3

  • homeobox protein NK-2 homolog 3

  • homeobox protein NK-2 homolog C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09329 NKX2-3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx2-3 NCBI NCBI:159296