Nkx2-3 - NK2 homeobox 3 Gene

Mus musculus

Also known as Nkx2.3; nkx2-C; tinman; Nkx-2.3

Gene ID: 18089 | Gene type: protein coding

About Nkx2-3

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ morphogenesis; hematopoietic or lymphoid organ development; and post-embryonic digestive tract morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo mesoderm; and spleen. Orthologous to human NKX2-3 (NK2 homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-3 Products(2)

mRNA	Protein	Name
NM_008699.2	NP_032725.1	homeobox protein Nkx-2.3
NM_008699.2	NP_032725.1	homeobox protein Nkx-2.3

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	12682228	MGI
acts upstream of or within CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within Peyer's patch development	IMP IMP: Inferred from mutant phenotype	10790368	MGI
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	38311164	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	10207146	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	38311164	MGI
acts upstream of or within gland morphogenesis	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	12682228	MGI
acts upstream of or within leukocyte homeostasis	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within leukocyte migration	IMP IMP: Inferred from mutant phenotype	10790368	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	10790368	MGI
acts upstream of or within macrophage differentiation	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within mucosa-associated lymphoid tissue development	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	12141427	MGI
acts upstream of or within plasma cell differentiation	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10790368	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within post-embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10207146	MGI
acts upstream of or within saliva secretion	IMP IMP: Inferred from mutant phenotype	38311164	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	10207146	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10926756	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	10926756	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-2.3

NK2 transcription factor related, locus 3	homeobox protein NK-2 homolog 3
homeobox protein NK-2 homolog C

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09329	NKX2-3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx2-3	NCBI	NCBI:159296

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