Nkx2-5 - NK2 homeobox 5 Gene

Mus musculus

Also known as Csx; Nkx2.5; tinman; Nkx-2.5

Gene ID: 18091 | Gene type: protein coding

About Nkx2-5

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including cardiac muscle tissue development; positive regulation of transcription by RNA polymerase II; and regulation of heart contraction. Acts upstream of or within several processes, including circulatory system development; hematopoietic or lymphoid organ development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; branchial arch; heart; and hemolymphoid system. Used to study atrial heart septal defect 7; congenital heart disease; hypoplastic left heart syndrome; and tetralogy of Fallot. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-5 Products(2)

mRNA	Protein	Name
NM_008700.2	NP_032726.1	homeobox protein Nkx-2.5
NM_008700.2	NP_032726.1	homeobox protein Nkx-2.5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8900044	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15363409	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8900044	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21379568	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8887666	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19483677	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8887666	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11042197	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Purkinje myocyte differentiation	IMP IMP: Inferred from mutant phenotype	17250822	MGI
acts upstream of or within adult heart development	IMP IMP: Inferred from mutant phenotype	7628699	MGI
acts upstream of apoptotic process	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within apoptotic process involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	16510504	MGI
involved in atrial cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	17234970	MGI
acts upstream of or within atrioventricular node cell development	IMP IMP: Inferred from mutant phenotype	19546853	MGI
acts upstream of or within atrioventricular node cell fate commitment	IMP IMP: Inferred from mutant phenotype	15109497	MGI
involved in atrioventricular node development	IMP IMP: Inferred from mutant phenotype	18689573	MGI
acts upstream of or within bundle of His development	IGI IGI: Inferred from genetic interaction	17604724	MGI
acts upstream of or within cardiac conduction system development	IGI IGI: Inferred from genetic interaction	21690310	MGI
involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19166829	MGI
involved in cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	9857019	MGI
acts upstream of or within cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	19035347	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	10021345	MGI
acts upstream of or within cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	17350578	MGI
acts upstream of or within cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	19546853	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	7628699	MGI
involved in cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	21640717	MGI
involved in cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16510504	MGI
acts upstream of or within cardiac ventricle formation	IGI IGI: Inferred from genetic interaction	19035347	MGI
acts upstream of or within cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	16510504	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within embryonic heart tube development	IGI IGI: Inferred from genetic interaction	15843414	MGI
acts upstream of or within embryonic heart tube left/right pattern formation	IMP IMP: Inferred from mutant phenotype	9192865	MGI
acts upstream of epithelial cell apoptotic process	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within heart contraction	IGI IGI: Inferred from genetic interaction	21690310	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10021345	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	16510504	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	7628699	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	11784028	MGI
involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17234970	MGI
acts upstream of or within heart trabecula formation	IMP IMP: Inferred from mutant phenotype	16510504	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	10021345	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19479054	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11889119	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12023302	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16510504	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19483677	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	19035347	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16510504	MGI
acts upstream of or within pharyngeal system development	IGI IGI: Inferred from genetic interaction	11390666	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11572777	MGI
involved in positive regulation of cardioblast differentiation	IMP IMP: Inferred from mutant phenotype	11889119	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	11390666	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	9857019	MGI
involved in positive regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	18689573	MGI
involved in positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	18689573	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8900044	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19578358	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12392994	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18689573	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	8887666	MGI
acts upstream of or within proepicardium development	IMP IMP: Inferred from mutant phenotype	18722343	MGI
acts upstream of or within pulmonary myocardium development	IMP IMP: Inferred from mutant phenotype	17823370	MGI
involved in regulation of cardiac conduction	IMP IMP: Inferred from mutant phenotype	18689573	MGI
acts upstream of or within regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	20713518	MGI
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	18689573	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14645532	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	22560297	MGI
involved in thyroid gland development	IMP IMP: Inferred from mutant phenotype	16418214	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17604724	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	10021345	MGI
acts upstream of or within ventricular cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	19546853	MGI
acts upstream of or within ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	15109497	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15653675	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14550786	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12023302	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	18285513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-2.5

Drosophila NK2 transcription factor related, locus 5	NK2 transcription factor related, locus 5
cardiac-specific homeobox	homeobox protein CSX
homeobox protein NK-2 homolog E

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160839	SPB-PEG4-AAD		/	Unkown
HY-103484	GATA4-NKX2-5-IN-1	Inhibitor	99.24%	Unkown
HY-108440	Shz-1		99.88%	Unkown
HY-RS09330	NKX2-5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx2-5	NCBI	NCBI:1482

Name
Email *

	Sorry, but the email address you supplied was invalid.