Nkx2-6 - NK2 homeobox 6 Gene

Also Known as Tix; Nkx2.6; tinman; Nkx-2.6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18092

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; digestive tract development; and pharyngeal system development. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and thymus. Orthologous to human NKX2-6 (NK2 homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-6 Products (4)

mRNA Protein Name
NM_001360218.1 NP_001347147.1 homeobox protein Nkx-2.6 isoform 2
NM_010920.2 NP_035050.2 homeobox protein Nkx-2.6 isoform 1
NM_001360218.1 NP_001347147.1 homeobox protein Nkx-2.6 isoform 2
NM_010920.2 NP_035050.2 homeobox protein Nkx-2.6 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
11390666 MGI
involved in atrial cardiac muscle cell development IEP
IEP: Inferred from expression pattern
9621431 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
11390666 MGI
involved in digestive tract development IEP
IEP: Inferred from expression pattern
9545560 MGI
involved in embryonic heart tube development IEP
IEP: Inferred from expression pattern
9545560 MGI
acts upstream of epithelial cell apoptotic process IGI
IGI: Inferred from genetic interaction
11390666 MGI
acts upstream of or within epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
11390666 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
11390666 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
11390666 MGI
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
9621431 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IGI
IGI: Inferred from genetic interaction
11390666 MGI
involved in pericardium development IEP
IEP: Inferred from expression pattern
9545560 MGI
involved in pharyngeal system development IEP
IEP: Inferred from expression pattern
9486544 MGI
acts upstream of or within pharyngeal system development IGI
IGI: Inferred from genetic interaction
11390666 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
11390666 MGI
involved in tongue development IEP
IEP: Inferred from expression pattern
9621431 MGI
involved in ventricular cardiac muscle cell development IEP
IEP: Inferred from expression pattern
9621431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-2.6

  • Drosophila NK2 transcription factor related, locus 6

  • NK2 transcription factor related, locus 6

  • homeobox protein NK-2 homolog F

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09331 NKX2-6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx2-6 NCBI NCBI:137814