2. Gene
  3. Nkx6-1 - NK6 homeobox 1 Gene

Nkx6-1 - NK6 homeobox 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NKX6A; Nkx6.1

Gene ID: 18096 | Gene type: protein coding

About Nkx6-1

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including neurogenesis; regulation of axon extension; and regulation of neuron migration. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; and gut. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx6-1 Products(2)

mRNA Protein Name
NM_144955.2 NP_659204.1 homeobox protein Nkx-6.1
NM_144955.2 NP_659204.1 homeobox protein Nkx-6.1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within central nervous system neuron differentiation IMP
IMP: Inferred from mutant phenotype
19592574 MGI
acts upstream of or within endocrine pancreas development IGI
IGI: Inferred from genetic interaction
15944193 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
15944193 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629702 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629702 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629701 MGI
acts upstream of or within pancreatic A cell differentiation IGI
IGI: Inferred from genetic interaction
15944193 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10830170 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
15629702 MGI
acts upstream of or within regulation of axon extension IMP
IMP: Inferred from mutant phenotype
19592574 MGI
acts upstream of or within regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
19592574 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
11567614 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11567614 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
15944193 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
14573534 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-6.1

Drosophila NK transcription factor related, gene family 6, locus 1

NK6 transcription factor related, locus 1

homeobox protein NK-6 homolog A

homeodomain transcription factor Nkx6.1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09335 NKX6-1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx6-1 NCBI NCBI:4825