Nrxn2 - neurexin II Gene

Also Known as mKIAA0921; 6430591O13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18190

Summary

Enables several functions, including Calcium Channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in postsynapse organization and signal transduction. Acts upstream of or within neurotransmitter secretion and synapse assembly. Part of protein-containing complex. Is expressed in several structures, including blood vessel; nervous system; and retina. Used to study autism spectrum disorder. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nrxn2 Products (4)

mRNA Protein Name
NM_001205234.2 NP_001192163.1 neurexin-2 isoform 1 precursor
NM_001205235.2 NP_001192164.1 neurexin-2 isoform 3 precursor
NM_001369363.1 NP_001356292.1 neurexin-2 isoform 4 precursor
NM_020253.4 NP_064649.2 neurexin-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel regulator activity IGI
IGI: Inferred from genetic interaction
12827191 MGI
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
21424692 MGI
enables neuroligin family protein binding IPI
IPI: Inferred from physical interaction
21424692 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21356198 MGI
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
21424692 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
12827191 MGI
involved in gephyrin clustering involved in postsynaptic density assembly IDA
IDA: Inferred from direct assay
21424692 MGI
involved in neuroligin clustering involved in postsynaptic membrane assembly IDA
IDA: Inferred from direct assay
21424692 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
12827191 MGI
involved in postsynaptic density protein 95 clustering IDA
IDA: Inferred from direct assay
21424692 MGI
involved in postsynaptic membrane assembly IDA
IDA: Inferred from direct assay
21424692 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
36608123 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
36608123 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
36608123 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
36608123 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
25745399 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IMP
IMP: Inferred from mutant phenotype
25745399 MGI
involved in signal transduction IDA
IDA: Inferred from direct assay
21424692 MGI
acts upstream of or within synapse assembly IGI
IGI: Inferred from genetic interaction
12827191 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25745399 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25745399 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
24613359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurexin-2

  • neurexin II alpha

  • neurexin II beta

  • neurexin-2-alpha

  • neurexin-2-beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09584 NRXN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21670 Nrxn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28188 Nrxn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrxn2 NCBI NCBI:9379