2. Gene
  3. Gpr143 - G protein-coupled receptor 143 Gene

Gpr143 - G protein-coupled receptor 143 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Oa1

Gene ID: 18241 | Gene type: protein coding

About Gpr143

Summary

Predicted to enable L-DOPA receptor activity; amino acid binding activity; and dopamine binding activity. Involved in regulation of melanosome organization and regulation of melanosome transport. Predicted to be located in several cellular components, including apical plasma membrane; lysosomal membrane; and melanosome. Predicted to be active in melanosome membrane and plasma membrane. Is expressed in several structures, including eye; hair follicle; and inner ear. Used to study ocular albinism. Human ortholog(s) of this gene implicated in congenital nystagmus 6. Orthologous to human GPR143 (G protein-coupled receptor 143). [provided by Alliance of Genome Resources, Apr 2022]

Gpr143 Products(1)

mRNA Protein Name
NM_010951.3 NP_035081.3 G-protein coupled receptor 143
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in regulation of melanosome organization IMP
IMP: Inferred from mutant phenotype
18697795 MGI
involved in regulation of melanosome transport IMP
IMP: Inferred from mutant phenotype
18697795 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G-protein coupled receptor 143

MOA1

homolog of human ocular albinism 1 (Nettleship-Falls)

ocular albinism type 1 protein homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05665 GPR143 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr143 NCBI NCBI:4935