2. Gene
  3. Oaz1 - ornithine decarboxylase antizyme 1 Gene

Oaz1 - ornithine decarboxylase antizyme 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AZ1; Oaz; AZ-1; ODC-Az; Antizyme

Gene ID: 18245 | Gene type: protein coding

About Oaz1

Summary

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

Oaz1 Products(2)

mRNA Protein Name
NM_001301034.1 NP_001287963.1 ornithine decarboxylase antizyme 1 isoform 2
NM_008753.4 NP_032779.2 ornithine decarboxylase antizyme 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ornithine decarboxylase inhibitor activity IDA
IDA: Inferred from direct assay
24967154 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24967154 MGI
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of intracellular protein transport IDA
IDA: Inferred from direct assay
19449338 MGI
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
24967154 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ornithine decarboxylase antizyme 1

antizyme 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09732 OAZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oaz1 NCBI NCBI:4946