Fxyd5 - FXYD domain-containing ion transport regulator 5 Gene

Also Known as RIC; EF-8; Oit2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18301

Summary

This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial Cadherin, a calcium-dependent adhesion protein and is associated with Cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Fxyd5 Products (4)

mRNA Protein Name
NM_001111073.2 NP_001104543.1 FXYD domain-containing ion transport regulator 5 isoform a precursor
NM_001287213.1 NP_001274142.1 FXYD domain-containing ion transport regulator 5 isoform a precursor
NM_001287217.1 NP_001274146.1 FXYD domain-containing ion transport regulator 5 isoform b precursor
NM_008761.4 NP_032787.1 FXYD domain-containing ion transport regulator 5 isoform a precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ion channel regulator activity IDA
IDA: Inferred from direct assay
16148001 MGI
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
16148001 MGI
enables sodium channel regulator activity IDA
IDA: Inferred from direct assay
16148001 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16148001 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FXYD domain-containing ion transport regulator 5

  • dysadherin

  • ion channel homolog RIC

  • oncoprotein induced transcript 2

  • oncoprotein-induced protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05169 FXYD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22521 Fxyd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29042 Fxyd5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fxyd5 NCBI NCBI:53827