Pafah1b1 - platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 Gene

Also Known as Lis1; Mdsh; LIS-1; Ms10u; Pafaha; MMS10-U

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18472

Summary

Enables identical protein binding activity; microtubule binding activity; and phosphoprotein binding activity. Involved in several processes, including cortical microtubule organization; establishment of planar polarity; and inner ear development. Acts upstream of or within several processes, including Cytoskeleton organization; nervous system development; and transport along microtubule. Located in several cellular components, including centrosome; perinuclear region of cytoplasm; and stereocilium. Part of microtubule associated complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pafah1b1 Products (1)

mRNA Protein Name
NM_013625.4 NP_038653.1 platelet-activating factor acetylhydrolase IB subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
11344260 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
11163259 MGI
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
14578885 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11231056 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of JNK cascade IGI
IGI: Inferred from genetic interaction
22073305 MGI
acts upstream of or within acrosome assembly IMP
IMP: Inferred from mutant phenotype
13129914 MGI
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
14507966 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
10541472 MGI
acts upstream of or within ameboidal-type cell migration IMP
IMP: Inferred from mutant phenotype
22073305 MGI
involved in auditory receptor cell development IMP
IMP: Inferred from mutant phenotype
23533177 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
12629176 MGI
acts upstream of or within cerebral cortex development IGI
IGI: Inferred from genetic interaction
18469343 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
11344260 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10729324 MGI
involved in cochlea development IMP
IMP: Inferred from mutant phenotype
23533177 MGI
involved in cortical microtubule organization IMP
IMP: Inferred from mutant phenotype
21844209 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
22073305 MGI
involved in establishment of planar polarity of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
23533177 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
17330141 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
10729324 MGI
acts upstream of or within interneuron migration IMP
IMP: Inferred from mutant phenotype
15331402 MGI
acts upstream of or within layer formation in cerebral cortex IGI
IGI: Inferred from genetic interaction
17330141 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
10541472 MGI
acts upstream of or within maintenance of centrosome location IMP
IMP: Inferred from mutant phenotype
23533177 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
16107726 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
22073305 MGI
involved in microtubule cytoskeleton organization involved in establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
23533177 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
29150182 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
29150182 MGI
acts upstream of or within myeloid leukocyte migration IMP
IMP: Inferred from mutant phenotype
22073305 MGI
acts upstream of or within negative regulation of JNK cascade IGI
IGI: Inferred from genetic interaction
22073305 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
12629176 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
10541472 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
12796778 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
9697693 MGI
acts upstream of or within nuclear membrane disassembly IMP
IMP: Inferred from mutant phenotype
18809722 MGI
acts upstream of or within osteoclast development IMP
IMP: Inferred from mutant phenotype
22073305 MGI
involved in positive regulation of cellular component organization IMP
IMP: Inferred from mutant phenotype
23533177 MGI
acts upstream of or within positive regulation of cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22073305 MGI
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
23483716 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
23533177 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
22073305 MGI
acts upstream of or within radial glia-guided pyramidal neuron migration IGI
IGI: Inferred from genetic interaction
16107726 MGI
involved in reelin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17330141 MGI
acts upstream of or within regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
14507966 MGI
involved in regulation of microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23533177 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
23483716 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
23483716 MGI
acts upstream of or within retrograde axonal transport IDA
IDA: Inferred from direct assay
11163259 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
17433713 MGI
acts upstream of or within vesicle transport along microtubule IGI
IGI: Inferred from genetic interaction
16107726 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
29150182 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
29150182 MGI
located in cell leading edge IDA
IDA: Inferred from direct assay
14691133 MGI
located in centrosome IDA
IDA: Inferred from direct assay
11163259 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12551946 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23483716 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23483716 MGI
part of microtubule associated complex IDA
IDA: Inferred from direct assay
11163259 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
13129914 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
17314247 MGI
NOT located in non-motile cilium IDA
IDA: Inferred from direct assay
17314247 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14578885 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
23533177 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-activating factor acetylhydrolase IB subunit beta

  • PAF acetylhydrolase 45 kDa subunit

  • PAF-AH 45 kDa subunit

  • PAF-AH alpha

  • PAFAH alpha

  • Pafaha/Lis1

  • lissencephaly-1 protein

  • platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

  • platelet-activating factor acetylhydrolase 45kD subunit

  • plate

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09967 PAFAH1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pafah1b1 NCBI NCBI:5048