Pax7 - paired box 7 Gene

Also Known as Pax-7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18509

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Apr 2022]

Pax7 Products (1)

mRNA Protein Name
NM_011039.3 NP_035169.1 paired box protein Pax-7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
34059674 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23070814 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22862948 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23070814 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
8631261 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
23070814 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
8631261 MGI
acts upstream of or within muscle tissue morphogenesis IGI
IGI: Inferred from genetic interaction
19531352 MGI
acts upstream of or within neuron fate commitment IGI
IGI: Inferred from genetic interaction
9858722 MGI
acts upstream of or within positive regulation of myoblast proliferation IMP
IMP: Inferred from mutant phenotype
22862948 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22862948 MGI
acts upstream of or within regulation of DNA binding IMP
IMP: Inferred from mutant phenotype
23070814 MGI
acts upstream of or within regulation of cell fate commitment IMP
IMP: Inferred from mutant phenotype
23070814 MGI
acts upstream of or within regulation of chromatin organization IDA
IDA: Inferred from direct assay
22862948 MGI
acts upstream of or within regulation of chromatin organization IGI
IGI: Inferred from genetic interaction
22862948 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23070814 MGI
acts upstream of or within skeletal muscle satellite cell commitment IMP
IMP: Inferred from mutant phenotype
11030621 MGI
involved in skeletal muscle satellite cell differentiation IDA
IDA: Inferred from direct assay
34059674 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
11030621 MGI
acts upstream of or within skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
9608680 MGI
acts upstream of or within spinal cord association neuron differentiation IGI
IGI: Inferred from genetic interaction
9858722 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22862948 MGI
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
34059674 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9230312 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paired box protein Pax-7

  • paired box gene 7

  • paired box transcription factor PAX7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10094 PAX7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174556 Human PAX7 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pax7 NCBI NCBI:5081