Pax7 - paired box 7 Gene

Mus musculus

Also known as Pax-7

Gene ID: 18509 | Gene type: protein coding

About Pax7

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Apr 2022]

Pax7 Products(1)

mRNA	Protein	Name
NM_011039.3	NP_035169.1	paired box protein Pax-7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	34059674	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23070814	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22862948	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23070814	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	8631261	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	23070814	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IDA IDA: Inferred from direct assay	18590716	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	8631261	MGI
acts upstream of or within muscle tissue morphogenesis	IGI IGI: Inferred from genetic interaction	19531352	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	9858722	MGI
acts upstream of or within positive regulation of myoblast proliferation	IMP IMP: Inferred from mutant phenotype	22862948	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22862948	MGI
acts upstream of or within regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	23070814	MGI
acts upstream of or within regulation of cell fate commitment	IMP IMP: Inferred from mutant phenotype	23070814	MGI
acts upstream of or within regulation of chromatin organization	IDA IDA: Inferred from direct assay	22862948	MGI
acts upstream of or within regulation of chromatin organization	IGI IGI: Inferred from genetic interaction	22862948	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23070814	MGI
acts upstream of or within skeletal muscle satellite cell commitment	IMP IMP: Inferred from mutant phenotype	11030621	MGI
involved in skeletal muscle satellite cell differentiation	IDA IDA: Inferred from direct assay	34059674	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	11030621	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	9608680	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	9858722	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22862948	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	34059674	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9230312	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired box protein Pax-7

paired box gene 7

paired box transcription factor PAX7

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10094	PAX7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174556	Human PAX7 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax7	NCBI	NCBI:5081

Name
Email *

	Sorry, but the email address you supplied was invalid.