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Pcnt - pericentrin (kendrin) Gene

Also Known as KEN; Pcnt2; kendrin; m239Asp; m275Asp

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18541

Summary

Predicted to enable Calmodulin binding activity and molecular adaptor activity. Acts upstream of or within several processes, including animal organ development; mitotic spindle organization; and neuron migration. Located in several cellular components, including cis-Golgi network; intercellular bridge; and microtubule organizing center. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; respiratory system; and sensory organ. Used to study microcephalic osteodysplastic primordial dwarfism type II. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Apr 2022]

Pcnt Products (2)

mRNA	Protein	Name
NM_001282992.1	NP_001269921.1	pericentrin isoform b
NM_008787.3	NP_032813.3	pericentrin isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9804427	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within brain morphogenesis	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	25220058	MGI
acts upstream of or within cerebellar cortex morphogenesis	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within embryonic brain development	IMP IMP: Inferred from mutant phenotype	25220058	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	25220058	MGI
acts upstream of or within head development	IMP IMP: Inferred from mutant phenotype	25220058	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	25220058	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	25220058	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within olfactory bulb development	IMP IMP: Inferred from mutant phenotype	20096683	MGI
acts upstream of or within spindle organization	IDA IDA: Inferred from direct assay	8124707	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	25220058	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	15037549	MGI
located in centrosome	IDA IDA: Inferred from direct assay	11555636	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	15337773	MGI
located in cis-Golgi network	IDA IDA: Inferred from direct assay	24145165	MGI
located in intercellular bridge	IDA IDA: Inferred from direct assay	20186884	MGI
located in microtubule organizing center	IDA IDA: Inferred from direct assay	8124707	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	15337773	MGI
located in pericentriolar material	IDA IDA: Inferred from direct assay	22031837	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pericentrin	pericentrin 2 pericentrin-250 pericentrin-360

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10161	PCNT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcnt	NCBI	NCBI:5116