Pde6b - phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Gene

Also Known as r; rd; rd1; Pdeb; rd-1; rd10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18587

Summary

Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in entrainment of circadian clock by photoperiod. Acts upstream of or within detection of light stimulus and retina development in camera-type eye. Located in photoreceptor outer segment. Is expressed in esophagus; eye; and male reproductive gland or organ. Used to study congenital stationary night blindness autosomal dominant 2; retinitis pigmentosa; and retinitis pigmentosa 40. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 2 and retinitis pigmentosa 40. Orthologous to human PDE6B (phosphodiesterase 6B). [provided by Alliance of Genome Resources, Apr 2022]

Pde6b Products (1)

mRNA Protein Name
NM_008806.2 NP_032832.2 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of light stimulus IMP
IMP: Inferred from mutant phenotype
11747369 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
30240620 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
Cellular Component GO Annotation Evidence References Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
22183407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

  • GMP-PDE beta

  • cGMP-phosphodiesterase beta-subunit

  • phosphodiesterase, cGMP, rod receptor, beta polypeptide

  • retinal degeneration 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10233 PDE6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde6b NCBI NCBI:5158