Pea15a - proliferation and apoptosis adaptor protein 15A Gene

Also Known as Mat1; Pea15; PEA-15; Pkcs15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18611

Summary

This gene encodes an adaptor protein that functions as a negative regulator of Apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and Caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to Insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Pea15a Products (3)

mRNA Protein Name
NM_001329869.1 NP_001316798.1 astrocytic phosphoprotein PEA-15 isoform 2
NM_001329871.1 NP_001316800.1 astrocytic phosphoprotein PEA-15 isoform 3
NM_011063.3 NP_035193.1 astrocytic phosphoprotein PEA-15 isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
10588860 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
10588860 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

astrocytic phosphoprotein PEA-15

  • 15 kDa phosphoprotein enriched in astrocytes

  • mammary transforming gene 1

  • phosphoprotein enriched in astrocytes 15

  • phosphoprotein enriched in astrocytes 15A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS25323 Pea15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown